Visceral Leishmaniasis Revealing Undiagnosed Inborn Errors of Immunity

Visceral Leishmaniasis (VL) is a potentially fatal disease and may be associated with primary or acquired immunodeficiencies. There are few reports, in the literature, of inborn errors of immunity. Here, we report two cases of VL as a marker of inborn errors of immunity, namely, GATA2 and RAB27A def...

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Detalles Bibliográficos
Autores principales: Carvalho, Daniel Gleison, Vasconcelos, Dewton de Moraes, Santos, Andreia Cristiane Rangel, Lindoso, Jose Angelo Lauletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637728/
https://www.ncbi.nlm.nih.gov/pubmed/37970879
http://dx.doi.org/10.1590/0037-8682-0322-2023
Descripción
Sumario:Visceral Leishmaniasis (VL) is a potentially fatal disease and may be associated with primary or acquired immunodeficiencies. There are few reports, in the literature, of inborn errors of immunity. Here, we report two cases of VL as a marker of inborn errors of immunity, namely, GATA2 and RAB27A deficiency. Our data suggest that VL patients should be screened for primary immunodeficiency, particularly in cases of VL relapse.

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