Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein

Chronic kidney disease (CKD) causes cognitive impairment and contributes to the overall global burden of dementia. However, mechanisms through which the kidneys and brain communicate are not fully understood. We established a CKD mouse model through adenine-induced tubulointerstitial fibrosis. Novel...

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Detalles Bibliográficos
Autores principales: Matsuki, Hisazumi, Mandai, Shintaro, Shiwaku, Hiroki, Koide, Takaaki, Takahashi, Naohiro, Yanagi, Tomoki, Inaba, Shunsuke, Ida, Saaya, Fujiki, Tamami, Mori, Yutaro, Ando, Fumiaki, Mori, Takayasu, Susa, Koichiro, Iimori, Soichiro, Sohara, Eisei, Takahashi, Hidehiko, Uchida, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637825/
https://www.ncbi.nlm.nih.gov/pubmed/37889501
http://dx.doi.org/10.18632/aging.205164

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