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The Saccharomyces cerevisiae acetyltransferase Gcn5 exerts antagonistic pleiotropic effects on chronological ageing

Compared to replicative lifespan, epigenetic regulation of chronological lifespan (CLS) is less well understood in yeast. Here, by screening all the viable mutants of histone acetyltransferase (HAT) and histone deacetylase (HDAC), we demonstrate that Gcn5, functioning in the HAT module of the SAGA/S...

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Detalles Bibliográficos
Autores principales:	Li, Kaiqiang, Mocciaro, Gabriele, Griffin, Jules L., Zhang, Nianshu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637828/ https://www.ncbi.nlm.nih.gov/pubmed/37874684 http://dx.doi.org/10.18632/aging.205109

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