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The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review

Plague remains endemic in many parts of the world, and despite efforts, no preventative vaccine is available. We performed a systemic review of available randomised controlled trials (RCTs) of live, attenuated, or killed plague vaccines vs. placebo, no intervention, or other plague vaccine to evalua...

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Autores principales: Hartley, Louise, Harold, Sydney, Hawe, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637890/
https://www.ncbi.nlm.nih.gov/pubmed/37954941
http://dx.doi.org/10.1016/j.crimmu.2023.100072
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author Hartley, Louise
Harold, Sydney
Hawe, Emma
author_facet Hartley, Louise
Harold, Sydney
Hawe, Emma
author_sort Hartley, Louise
collection PubMed
description Plague remains endemic in many parts of the world, and despite efforts, no preventative vaccine is available. We performed a systemic review of available randomised controlled trials (RCTs) of live, attenuated, or killed plague vaccines vs. placebo, no intervention, or other plague vaccine to evaluate their efficacy, safety, and immunogenicity. Data sources included MEDLINE, Embase, and the Cochrane Library; clinical trial registers; and reference lists of included studies. Primary outcomes were efficacy, safety, and immunogenicity. Risk of bias was assessed using the Cochrane Collaborations tool. Only 2 RCTs, both on subunit vaccines, were included out of the 75 screened articles. The 2 trials included 240 participants with a follow-up of 3 months and 60 participants with a follow-up of 13 months, respectively. Safety evidence was limited, but both vaccines were well tolerated, with only mild to moderate adverse events. Both vaccines were immunogenic in a dose-dependent manner. However, given the limited data identified in this systematic review, we are unable to quantify the efficacy of vaccines to prevent plague, as well as their long-term safety and immunogenicity. More trials of plague vaccines are needed to generate additional evidence of their long-term effects.
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spelling pubmed-106378902023-11-11 The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review Hartley, Louise Harold, Sydney Hawe, Emma Curr Res Immunol Review Article Plague remains endemic in many parts of the world, and despite efforts, no preventative vaccine is available. We performed a systemic review of available randomised controlled trials (RCTs) of live, attenuated, or killed plague vaccines vs. placebo, no intervention, or other plague vaccine to evaluate their efficacy, safety, and immunogenicity. Data sources included MEDLINE, Embase, and the Cochrane Library; clinical trial registers; and reference lists of included studies. Primary outcomes were efficacy, safety, and immunogenicity. Risk of bias was assessed using the Cochrane Collaborations tool. Only 2 RCTs, both on subunit vaccines, were included out of the 75 screened articles. The 2 trials included 240 participants with a follow-up of 3 months and 60 participants with a follow-up of 13 months, respectively. Safety evidence was limited, but both vaccines were well tolerated, with only mild to moderate adverse events. Both vaccines were immunogenic in a dose-dependent manner. However, given the limited data identified in this systematic review, we are unable to quantify the efficacy of vaccines to prevent plague, as well as their long-term safety and immunogenicity. More trials of plague vaccines are needed to generate additional evidence of their long-term effects. Elsevier 2023-11-01 /pmc/articles/PMC10637890/ /pubmed/37954941 http://dx.doi.org/10.1016/j.crimmu.2023.100072 Text en © 2023 RTI Health Solutions https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Hartley, Louise
Harold, Sydney
Hawe, Emma
The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review
title The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review
title_full The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review
title_fullStr The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review
title_full_unstemmed The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review
title_short The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review
title_sort efficacy, safety, and immunogenicity of plague vaccines: a systematic literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637890/
https://www.ncbi.nlm.nih.gov/pubmed/37954941
http://dx.doi.org/10.1016/j.crimmu.2023.100072
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