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The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review
Plague remains endemic in many parts of the world, and despite efforts, no preventative vaccine is available. We performed a systemic review of available randomised controlled trials (RCTs) of live, attenuated, or killed plague vaccines vs. placebo, no intervention, or other plague vaccine to evalua...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637890/ https://www.ncbi.nlm.nih.gov/pubmed/37954941 http://dx.doi.org/10.1016/j.crimmu.2023.100072 |
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author | Hartley, Louise Harold, Sydney Hawe, Emma |
author_facet | Hartley, Louise Harold, Sydney Hawe, Emma |
author_sort | Hartley, Louise |
collection | PubMed |
description | Plague remains endemic in many parts of the world, and despite efforts, no preventative vaccine is available. We performed a systemic review of available randomised controlled trials (RCTs) of live, attenuated, or killed plague vaccines vs. placebo, no intervention, or other plague vaccine to evaluate their efficacy, safety, and immunogenicity. Data sources included MEDLINE, Embase, and the Cochrane Library; clinical trial registers; and reference lists of included studies. Primary outcomes were efficacy, safety, and immunogenicity. Risk of bias was assessed using the Cochrane Collaborations tool. Only 2 RCTs, both on subunit vaccines, were included out of the 75 screened articles. The 2 trials included 240 participants with a follow-up of 3 months and 60 participants with a follow-up of 13 months, respectively. Safety evidence was limited, but both vaccines were well tolerated, with only mild to moderate adverse events. Both vaccines were immunogenic in a dose-dependent manner. However, given the limited data identified in this systematic review, we are unable to quantify the efficacy of vaccines to prevent plague, as well as their long-term safety and immunogenicity. More trials of plague vaccines are needed to generate additional evidence of their long-term effects. |
format | Online Article Text |
id | pubmed-10637890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106378902023-11-11 The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review Hartley, Louise Harold, Sydney Hawe, Emma Curr Res Immunol Review Article Plague remains endemic in many parts of the world, and despite efforts, no preventative vaccine is available. We performed a systemic review of available randomised controlled trials (RCTs) of live, attenuated, or killed plague vaccines vs. placebo, no intervention, or other plague vaccine to evaluate their efficacy, safety, and immunogenicity. Data sources included MEDLINE, Embase, and the Cochrane Library; clinical trial registers; and reference lists of included studies. Primary outcomes were efficacy, safety, and immunogenicity. Risk of bias was assessed using the Cochrane Collaborations tool. Only 2 RCTs, both on subunit vaccines, were included out of the 75 screened articles. The 2 trials included 240 participants with a follow-up of 3 months and 60 participants with a follow-up of 13 months, respectively. Safety evidence was limited, but both vaccines were well tolerated, with only mild to moderate adverse events. Both vaccines were immunogenic in a dose-dependent manner. However, given the limited data identified in this systematic review, we are unable to quantify the efficacy of vaccines to prevent plague, as well as their long-term safety and immunogenicity. More trials of plague vaccines are needed to generate additional evidence of their long-term effects. Elsevier 2023-11-01 /pmc/articles/PMC10637890/ /pubmed/37954941 http://dx.doi.org/10.1016/j.crimmu.2023.100072 Text en © 2023 RTI Health Solutions https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Hartley, Louise Harold, Sydney Hawe, Emma The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review |
title | The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review |
title_full | The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review |
title_fullStr | The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review |
title_full_unstemmed | The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review |
title_short | The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review |
title_sort | efficacy, safety, and immunogenicity of plague vaccines: a systematic literature review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637890/ https://www.ncbi.nlm.nih.gov/pubmed/37954941 http://dx.doi.org/10.1016/j.crimmu.2023.100072 |
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