Intralumenal docking of connexin 36 channels in the ER isolates mistrafficked protein

The intracellular domains of connexins are essential for the assembly of gap junctions. For connexin 36 (Cx36), the major neuronal connexin, it has been shown that a dysfunctional PDZ-binding motif interferes with electrical synapse formation. However, it is still unknown how this motif coordinates...

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Detalles Bibliográficos
Autores principales: Tetenborg, Stephan, Liss, Viktoria, Breitsprecher, Leonhard, Timonina, Ksenia, Kotova, Anna, Acevedo Harnecker, Alejandra Jesús, Yuan, Chunxu, Shihabeddin, Eyad, Ariakia, Fatemeh, Qin, Guoting, Chengzhi, Cai, Dedek, Karin, Zoidl, Georg, Hensel, Michael, O’Brien, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637963/
https://www.ncbi.nlm.nih.gov/pubmed/37742923
http://dx.doi.org/10.1016/j.jbc.2023.105282

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