Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity

Ubiquitin-specific proteases (USPs) are crucial for controlling cellular proteostasis and signaling pathways but how deubiquitination is selective remains poorly understood, in particular between paralogues. Here, we developed a fusion tag method by mining the Protein Data Bank and trapped USP11, a...

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Detalles Bibliográficos
Autores principales: Maurer, Sigrun K., Mayer, Matthias P., Ward, Stephanie J., Boudjema, Sana, Halawa, Mohamed, Zhang, Jiatong, Caulton, Simon G., Emsley, Jonas, Dreveny, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637973/
https://www.ncbi.nlm.nih.gov/pubmed/37777157
http://dx.doi.org/10.1016/j.jbc.2023.105300

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