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Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis

INTRODUCTION: Proton pump inhibitors (PPIs) show a high level of efficacy and a high safety profile, and they have been increasingly prescribed in recent years. However, recent pharmacoepidemiological evidence has shown that PPI use has been associated with health risks and complications. OBJECTIVES...

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Autores principales: Algabbani, Aljoharah M., Alangari, Abdulaziz S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638047/
https://www.ncbi.nlm.nih.gov/pubmed/37961073
http://dx.doi.org/10.1016/j.jsps.2023.101841
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author Algabbani, Aljoharah M.
Alangari, Abdulaziz S.
author_facet Algabbani, Aljoharah M.
Alangari, Abdulaziz S.
author_sort Algabbani, Aljoharah M.
collection PubMed
description INTRODUCTION: Proton pump inhibitors (PPIs) show a high level of efficacy and a high safety profile, and they have been increasingly prescribed in recent years. However, recent pharmacoepidemiological evidence has shown that PPI use has been associated with health risks and complications. OBJECTIVES: This study aimed to assess the prescribing patterns of proton pump inhibitors and the prevalence of potential drug–drug interactions (DDIs) among patients who use PPIs. METHOD: This was a retrospective analysis of electronic health records from the Ministry of National Guard Hospitals in Riyadh from January 2019 to June 2022. All adult patients who used PPIs were included to assess the prescribing patterns and drug utilization, including the number of prescriptions, duration of prescriptions, number of doses, and prescription indications. Potential DDIs were assessed based on concurrent use, which is defined as taking an interacting drug parallel to PPIs. The assessment includes complete or partial overlapping, with at least one day of overlapping. RESULTS: The total number of PPI prescriptions was 80,365 for a total of 9,930 patients with a mean age of 67.5. The majority of PPIs were prescribed in high doses (74%), without reporting appropriate indications (95%), and 17% were prescribed for long-term use. A total of 24,575 (33.6%) potential DDIs with PPIs were found. CONCLUSION: The results showed that the majority of the PPI prescriptions were made with a high number of doses, without reporting appropriate indications, with some having potential DDIs. This might result in exposing patients to an increasing number of health risks. The findings highlight the importance of implementing a stewardship program for PPI prescription with periodic reassessments of patients’ needs for these medications.
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spelling pubmed-106380472023-11-13 Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis Algabbani, Aljoharah M. Alangari, Abdulaziz S. Saudi Pharm J Article INTRODUCTION: Proton pump inhibitors (PPIs) show a high level of efficacy and a high safety profile, and they have been increasingly prescribed in recent years. However, recent pharmacoepidemiological evidence has shown that PPI use has been associated with health risks and complications. OBJECTIVES: This study aimed to assess the prescribing patterns of proton pump inhibitors and the prevalence of potential drug–drug interactions (DDIs) among patients who use PPIs. METHOD: This was a retrospective analysis of electronic health records from the Ministry of National Guard Hospitals in Riyadh from January 2019 to June 2022. All adult patients who used PPIs were included to assess the prescribing patterns and drug utilization, including the number of prescriptions, duration of prescriptions, number of doses, and prescription indications. Potential DDIs were assessed based on concurrent use, which is defined as taking an interacting drug parallel to PPIs. The assessment includes complete or partial overlapping, with at least one day of overlapping. RESULTS: The total number of PPI prescriptions was 80,365 for a total of 9,930 patients with a mean age of 67.5. The majority of PPIs were prescribed in high doses (74%), without reporting appropriate indications (95%), and 17% were prescribed for long-term use. A total of 24,575 (33.6%) potential DDIs with PPIs were found. CONCLUSION: The results showed that the majority of the PPI prescriptions were made with a high number of doses, without reporting appropriate indications, with some having potential DDIs. This might result in exposing patients to an increasing number of health risks. The findings highlight the importance of implementing a stewardship program for PPI prescription with periodic reassessments of patients’ needs for these medications. Elsevier 2023-12 2023-10-21 /pmc/articles/PMC10638047/ /pubmed/37961073 http://dx.doi.org/10.1016/j.jsps.2023.101841 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Algabbani, Aljoharah M.
Alangari, Abdulaziz S.
Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis
title Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis
title_full Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis
title_fullStr Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis
title_full_unstemmed Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis
title_short Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis
title_sort proton pump inhibitor prescribing patterns and utilization: a retrospective chart review analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638047/
https://www.ncbi.nlm.nih.gov/pubmed/37961073
http://dx.doi.org/10.1016/j.jsps.2023.101841
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