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Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China
Plumula nelumbinis, a widely used traditional Chinese medicine known for its calming and nerve-soothing properties, contains essential oil as a primary component. However, research on P. nelumbinis essential oil (PNEO) is limited. This study aimed to investigate PNEO components, network target analy...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638055/ https://www.ncbi.nlm.nih.gov/pubmed/37961070 http://dx.doi.org/10.1016/j.jsps.2023.101829 |
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author | Huang, Yujing Wang, Likang Xie, Juntao Chen, Haoming Ou, Guanrong Zeng, Liya Li, Yexin Li, Weizhen Fan, Hongxia Zheng, Junxia |
author_facet | Huang, Yujing Wang, Likang Xie, Juntao Chen, Haoming Ou, Guanrong Zeng, Liya Li, Yexin Li, Weizhen Fan, Hongxia Zheng, Junxia |
author_sort | Huang, Yujing |
collection | PubMed |
description | Plumula nelumbinis, a widely used traditional Chinese medicine known for its calming and nerve-soothing properties, contains essential oil as a primary component. However, research on P. nelumbinis essential oil (PNEO) is limited. This study aimed to investigate PNEO components, network target analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and antioxidant activity of P. nelumbinis from ten different habitats. GC–MS analysis identified 14 compounds in the essential oil, with CP12 (β-Sitosterol) having the highest concentration. Five compounds were identified for the first time in P. nelumbinis, with three of them reported for the first time in the Nelumbo. Network target analysis revealed 185 potential targets for 11 compounds and GO and KEGG enrichment analyses showed that PNEO was mainly located in the plasma membrane and could regulate a variety of molecular functions. KEGG pathway enrichment analysis revealed that the essential oil was primarily enriched in pathways related to cancer and the nervous system. PNEO demonstrated strong antioxidant activity, with N(8) (Fujiannanping) showing the highest ABTS scavenging capacity and N(7) (Hunanxiangtan) showing the highest DPPH radical scavenging capacity. Cell experiments showed that CP4, CP5 and CP10 had protective effects against H(2)O(2)-induced oxidative damage. The study suggests that P. nelumbinis from different regions may have slightly different pharmacological effects due to the presence of unique compounds, and further research is necessary to explore the potential therapeutic benefits of PNEO. |
format | Online Article Text |
id | pubmed-10638055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106380552023-11-13 Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China Huang, Yujing Wang, Likang Xie, Juntao Chen, Haoming Ou, Guanrong Zeng, Liya Li, Yexin Li, Weizhen Fan, Hongxia Zheng, Junxia Saudi Pharm J Original Article Plumula nelumbinis, a widely used traditional Chinese medicine known for its calming and nerve-soothing properties, contains essential oil as a primary component. However, research on P. nelumbinis essential oil (PNEO) is limited. This study aimed to investigate PNEO components, network target analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and antioxidant activity of P. nelumbinis from ten different habitats. GC–MS analysis identified 14 compounds in the essential oil, with CP12 (β-Sitosterol) having the highest concentration. Five compounds were identified for the first time in P. nelumbinis, with three of them reported for the first time in the Nelumbo. Network target analysis revealed 185 potential targets for 11 compounds and GO and KEGG enrichment analyses showed that PNEO was mainly located in the plasma membrane and could regulate a variety of molecular functions. KEGG pathway enrichment analysis revealed that the essential oil was primarily enriched in pathways related to cancer and the nervous system. PNEO demonstrated strong antioxidant activity, with N(8) (Fujiannanping) showing the highest ABTS scavenging capacity and N(7) (Hunanxiangtan) showing the highest DPPH radical scavenging capacity. Cell experiments showed that CP4, CP5 and CP10 had protective effects against H(2)O(2)-induced oxidative damage. The study suggests that P. nelumbinis from different regions may have slightly different pharmacological effects due to the presence of unique compounds, and further research is necessary to explore the potential therapeutic benefits of PNEO. Elsevier 2023-12 2023-10-18 /pmc/articles/PMC10638055/ /pubmed/37961070 http://dx.doi.org/10.1016/j.jsps.2023.101829 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Huang, Yujing Wang, Likang Xie, Juntao Chen, Haoming Ou, Guanrong Zeng, Liya Li, Yexin Li, Weizhen Fan, Hongxia Zheng, Junxia Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China |
title | Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China |
title_full | Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China |
title_fullStr | Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China |
title_full_unstemmed | Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China |
title_short | Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China |
title_sort | exploring the chemical composition, medicinal benefits, and antioxidant activity of plumula nelumbinis essential oil from different habitats in china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638055/ https://www.ncbi.nlm.nih.gov/pubmed/37961070 http://dx.doi.org/10.1016/j.jsps.2023.101829 |
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