Cargando…

Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China

Plumula nelumbinis, a widely used traditional Chinese medicine known for its calming and nerve-soothing properties, contains essential oil as a primary component. However, research on P. nelumbinis essential oil (PNEO) is limited. This study aimed to investigate PNEO components, network target analy...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yujing, Wang, Likang, Xie, Juntao, Chen, Haoming, Ou, Guanrong, Zeng, Liya, Li, Yexin, Li, Weizhen, Fan, Hongxia, Zheng, Junxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638055/
https://www.ncbi.nlm.nih.gov/pubmed/37961070
http://dx.doi.org/10.1016/j.jsps.2023.101829
_version_ 1785146549758590976
author Huang, Yujing
Wang, Likang
Xie, Juntao
Chen, Haoming
Ou, Guanrong
Zeng, Liya
Li, Yexin
Li, Weizhen
Fan, Hongxia
Zheng, Junxia
author_facet Huang, Yujing
Wang, Likang
Xie, Juntao
Chen, Haoming
Ou, Guanrong
Zeng, Liya
Li, Yexin
Li, Weizhen
Fan, Hongxia
Zheng, Junxia
author_sort Huang, Yujing
collection PubMed
description Plumula nelumbinis, a widely used traditional Chinese medicine known for its calming and nerve-soothing properties, contains essential oil as a primary component. However, research on P. nelumbinis essential oil (PNEO) is limited. This study aimed to investigate PNEO components, network target analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and antioxidant activity of P. nelumbinis from ten different habitats. GC–MS analysis identified 14 compounds in the essential oil, with CP12 (β-Sitosterol) having the highest concentration. Five compounds were identified for the first time in P. nelumbinis, with three of them reported for the first time in the Nelumbo. Network target analysis revealed 185 potential targets for 11 compounds and GO and KEGG enrichment analyses showed that PNEO was mainly located in the plasma membrane and could regulate a variety of molecular functions. KEGG pathway enrichment analysis revealed that the essential oil was primarily enriched in pathways related to cancer and the nervous system. PNEO demonstrated strong antioxidant activity, with N(8) (Fujiannanping) showing the highest ABTS scavenging capacity and N(7) (Hunanxiangtan) showing the highest DPPH radical scavenging capacity. Cell experiments showed that CP4, CP5 and CP10 had protective effects against H(2)O(2)-induced oxidative damage. The study suggests that P. nelumbinis from different regions may have slightly different pharmacological effects due to the presence of unique compounds, and further research is necessary to explore the potential therapeutic benefits of PNEO.
format Online
Article
Text
id pubmed-10638055
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-106380552023-11-13 Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China Huang, Yujing Wang, Likang Xie, Juntao Chen, Haoming Ou, Guanrong Zeng, Liya Li, Yexin Li, Weizhen Fan, Hongxia Zheng, Junxia Saudi Pharm J Original Article Plumula nelumbinis, a widely used traditional Chinese medicine known for its calming and nerve-soothing properties, contains essential oil as a primary component. However, research on P. nelumbinis essential oil (PNEO) is limited. This study aimed to investigate PNEO components, network target analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and antioxidant activity of P. nelumbinis from ten different habitats. GC–MS analysis identified 14 compounds in the essential oil, with CP12 (β-Sitosterol) having the highest concentration. Five compounds were identified for the first time in P. nelumbinis, with three of them reported for the first time in the Nelumbo. Network target analysis revealed 185 potential targets for 11 compounds and GO and KEGG enrichment analyses showed that PNEO was mainly located in the plasma membrane and could regulate a variety of molecular functions. KEGG pathway enrichment analysis revealed that the essential oil was primarily enriched in pathways related to cancer and the nervous system. PNEO demonstrated strong antioxidant activity, with N(8) (Fujiannanping) showing the highest ABTS scavenging capacity and N(7) (Hunanxiangtan) showing the highest DPPH radical scavenging capacity. Cell experiments showed that CP4, CP5 and CP10 had protective effects against H(2)O(2)-induced oxidative damage. The study suggests that P. nelumbinis from different regions may have slightly different pharmacological effects due to the presence of unique compounds, and further research is necessary to explore the potential therapeutic benefits of PNEO. Elsevier 2023-12 2023-10-18 /pmc/articles/PMC10638055/ /pubmed/37961070 http://dx.doi.org/10.1016/j.jsps.2023.101829 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Huang, Yujing
Wang, Likang
Xie, Juntao
Chen, Haoming
Ou, Guanrong
Zeng, Liya
Li, Yexin
Li, Weizhen
Fan, Hongxia
Zheng, Junxia
Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China
title Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China
title_full Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China
title_fullStr Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China
title_full_unstemmed Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China
title_short Exploring the chemical composition, medicinal benefits, and antioxidant activity of Plumula nelumbinis essential oil from different habitats in China
title_sort exploring the chemical composition, medicinal benefits, and antioxidant activity of plumula nelumbinis essential oil from different habitats in china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638055/
https://www.ncbi.nlm.nih.gov/pubmed/37961070
http://dx.doi.org/10.1016/j.jsps.2023.101829
work_keys_str_mv AT huangyujing exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT wanglikang exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT xiejuntao exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT chenhaoming exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT ouguanrong exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT zengliya exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT liyexin exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT liweizhen exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT fanhongxia exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina
AT zhengjunxia exploringthechemicalcompositionmedicinalbenefitsandantioxidantactivityofplumulanelumbinisessentialoilfromdifferenthabitatsinchina