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Replacing Lu-177 with Tb-161 in DOTA-TATE and PSMA-617 therapy: potential dosimetric implications for activity selection

AIM: To explore the dosimetric effect of substituting Lu-177 with Tb-161 in targeted radionuclide therapy (TRT) using the registered tracers DOTA-TATE and PSMA-617. METHODS: Using established kinetic data for [(177)Lu]Lu-DOTA-TATE and [(177)Lu]Lu-PSMA-617, radiation absorbed doses to typical tumour...

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Detalles Bibliográficos
Autores principales: Verburg, Frederik A., de Blois, Erik, Koolen, Stijn, Konijnenberg, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638215/
https://www.ncbi.nlm.nih.gov/pubmed/37947917
http://dx.doi.org/10.1186/s40658-023-00589-w