Mining cancer genomes for change-of-metabolic-function mutations

Enzymes with novel functions are needed to enable new organic synthesis techniques. Drawing inspiration from gain-of-function cancer mutations that functionally alter proteins and affect cellular metabolism, we developed METIS (Mutated Enzymes from Tumors In silico Screen). METIS identifies metaboli...

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Detalles Bibliográficos
Autores principales: Tu, Kevin J., Diplas, Bill H., Regal, Joshua A., Waitkus, Matthew S., Pirozzi, Christopher J., Reitman, Zachary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638295/
https://www.ncbi.nlm.nih.gov/pubmed/37950065
http://dx.doi.org/10.1038/s42003-023-05475-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638295/
https://www.ncbi.nlm.nih.gov/pubmed/37950065
http://dx.doi.org/10.1038/s42003-023-05475-w

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