Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators C-terminal binding proteins (CtBP) 1 and 2 are highly overexpressed in human PDAC, and CRISPR-based homozygous deletion of Ctbp2 in a mouse PDAC cell line (C...

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Detalles Bibliográficos
Autores principales: Chougoni, Kranthi Kumar, Park, Haemin, Damle, Priyadarshan K., Mason, Travis, Cheng, Bo, Dcona, Martin M., Szomju, Barbara, Dozmorov, Mikhail G., Idowu, Michael O., Grossman, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638350/
https://www.ncbi.nlm.nih.gov/pubmed/37949862
http://dx.doi.org/10.1038/s41389-023-00498-8

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