Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives

(−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral bioavailability is moderate, which is unfavorable for medicina...

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Detalles Bibliográficos
Autores principales: Lőrincz, Eszter Boglárka, Tóth, Gergely, Spolárics, Júlia, Herczeg, Mihály, Hodek, Jan, Zupkó, István, Minorics, Renáta, Ádám, Dorottya, Oláh, Attila, Zouboulis, Christos C., Weber, Jan, Nagy, Lajos, Ostorházi, Eszter, Bácskay, Ildikó, Borbás, Anikó, Herczegh, Pál, Bereczki, Ilona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638401/
https://www.ncbi.nlm.nih.gov/pubmed/37949940
http://dx.doi.org/10.1038/s41598-023-45565-7

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