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A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

AAA+ proteases degrade intracellular proteins in a highly specific manner. E. coli ClpXP, for example, relies on a C-terminal ssrA tag or other terminal degron sequences to recognize proteins, which are then unfolded by ClpX and subsequently translocated through its axial channel and into the degrad...

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Detalles Bibliográficos
Autores principales:	Ghanbarpour, Alireza, Cohen, Steven E., Fei, Xue, Kinman, Laurel F., Bell, Tristan A., Zhang, Jia Jia, Baker, Tania A., Davis, Joseph H., Sauer, Robert T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638403/ https://www.ncbi.nlm.nih.gov/pubmed/37949857 http://dx.doi.org/10.1038/s41467-023-43145-x

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