Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic liver disease. We report the cryo-EM structure o...

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Detalles Bibliográficos
Autores principales: Liu, Hongtao, Irobalieva, Rossitza N., Kowal, Julia, Ni, Dongchun, Nosol, Kamil, Bang-Sørensen, Rose, Lancien, Loïck, Stahlberg, Henning, Stieger, Bruno, Locher, Kaspar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638440/
https://www.ncbi.nlm.nih.gov/pubmed/37949847
http://dx.doi.org/10.1038/s41467-023-43109-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638440/
https://www.ncbi.nlm.nih.gov/pubmed/37949847
http://dx.doi.org/10.1038/s41467-023-43109-1

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