Cargando…

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic liver disease. We report the cryo-EM structure o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hongtao, Irobalieva, Rossitza N., Kowal, Julia, Ni, Dongchun, Nosol, Kamil, Bang-Sørensen, Rose, Lancien, Loïck, Stahlberg, Henning, Stieger, Bruno, Locher, Kaspar P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638440/ https://www.ncbi.nlm.nih.gov/pubmed/37949847 http://dx.doi.org/10.1038/s41467-023-43109-1

Ejemplares similares

Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver
por: Liu, Hongtao, et al.
Publicado: (2022)

The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP
por: van Beusekom, Cyrina D, et al.
Publicado: (2013)

Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP
por: Jain, Sankalp, et al.
Publicado: (2017)

Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase
por: Ramírez, Ana S., et al.
Publicado: (2022)

Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver
por: Tan, Xinle, et al.
Publicado: (2017)

Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression
por: Wu, Guixin, et al.
Publicado: (2018)

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
por: Yu, Qin, et al.
Publicado: (2021)

Structure of human drug transporters OATP1B1 and OATP1B3
por: Ciută, Anca-Denise, et al.
Publicado: (2023)

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)
por: Pedersen, Jenny M., et al.
Publicado: (2013)

The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies
por: Sohail, Muhammad Imran, et al.
Publicado: (2021)

Cell-based BSEP trans-inhibition: A novel, non-invasive test for diagnosis of antibody-induced BSEP deficiency
por: Stindt, Jan, et al.
Publicado: (2023)

Bsep expression in hilar cholangiocarcinoma of rat model
por: Zhang, Meng-yu, et al.
Publicado: (2021)

Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile
por: Xiong, Xiao-Li, et al.
Publicado: (2019)

Differential effects of metformin‐mediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial
por: Metry, Melissa, et al.
Publicado: (2022)

Role of polymorphic bile salt export pump (BSEP, ABCB11) transporters in anti-tuberculosis drug-induced liver injury in a Chinese cohort
por: Chen, Ru, et al.
Publicado: (2016)

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states
por: Manolaridis, Ioannis, et al.
Publicado: (2018)

Serum Bile Acid Profiling and Mixed Model Analysis Reveal Biomarkers Associated with Pruritus Reduction in Maralixibat-Treated Patients with BSEP Deficiency
por: Zhao, Xueheng, et al.
Publicado: (2022)

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
por: Alam, Amer, et al.
Publicado: (2018)

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase
por: Bloch, Joël S., et al.
Publicado: (2023)

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury
por: Woodhead, Jeffrey L., et al.
Publicado: (2014)

Histological demonstration of BSEP/ABCB11 inhibition in transient neonatal cholestasis: a case report
por: Baghdasaryan, Anna, et al.
Publicado: (2020)

Absence of Bsep/Abcb11 attenuates MCD diet‐induced hepatic steatosis but aggravates inflammation in mice
por: Fuchs, Claudia D., et al.
Publicado: (2020)

Activation mechanism of a short argonaute-TIR prokaryotic immune system
por: Ni, Dongchun, et al.
Publicado: (2023)

Evaluation metrics and validation of presence-only species distribution models based on distributional maps with varying coverage
por: Konowalik, Kamil, et al.
Publicado: (2021)

Structural basis of sodium-dependent bile salt uptake into the liver
por: Goutam, Kapil, et al.
Publicado: (2022)

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter
por: Miyauchi, Hirotake, et al.
Publicado: (2017)

Influence of DNA sequence on the structure of minicircles under torsional stress
por: Wang, Qian, et al.
Publicado: (2017)

Detergent Screening and Purification of the Human Liver ABC Transporters BSEP (ABCB11) and MDR3 (ABCB4) Expressed in the Yeast Pichia pastoris
por: Ellinger, Philipp, et al.
Publicado: (2013)

Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase
por: Ramírez, Ana S., et al.
Publicado: (2018)

Structural insights into the regulation of Cas7-11 by TPR-CHAT
por: Ekundayo, Babatunde, et al.
Publicado: (2022)

Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody
por: Perez, Camilo, et al.
Publicado: (2017)

Structural basis of transcobalamin recognition by human CD320 receptor
por: Alam, Amer, et al.
Publicado: (2016)

Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM
por: Righetto, Ricardo D., et al.
Publicado: (2019)

The complex structure of bile salt hydrolase from Lactobacillus salivarius reveals the structural basis of substrate specificity
por: Xu, Fuzhou, et al.
Publicado: (2019)

Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels
por: Rangl, Martina, et al.
Publicado: (2016)

Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2
por: Rasouli, Ali, et al.
Publicado: (2022)

Structural basis of the alternating-access mechanism in a bile acid transporter
por: Zhou, Xiaoming, et al.
Publicado: (2013)

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
por: Ni, Dongchun, et al.
Publicado: (2023)

Structure of a membrane-bound menaquinol:organohalide oxidoreductase
por: Cimmino, Lorenzo, et al.
Publicado: (2023)

Bile Salts by the Back Road
por: Oude Elferink, Ronald P.J., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_246mgf3plm4lsmkip4ig7aeh6b