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Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study

Uridine, a pyrimidine nucleoside, is crucial in the synthesis of metabolites. According to observational studies, a higher plasma uridine level is associated with a lower risk of atrial fibrillation (AF). However, the casual relationship between uridine and AF is still unknown. In this study, we use...

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Autores principales: Xu, Xintian, Zhang, Xiaoyu, Cheng, Shiyao, Li, Qinglang, Chen, Cai, Ouyang, Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638443/
https://www.ncbi.nlm.nih.gov/pubmed/37950049
http://dx.doi.org/10.1038/s41598-023-47025-8
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author Xu, Xintian
Zhang, Xiaoyu
Cheng, Shiyao
Li, Qinglang
Chen, Cai
Ouyang, Mao
author_facet Xu, Xintian
Zhang, Xiaoyu
Cheng, Shiyao
Li, Qinglang
Chen, Cai
Ouyang, Mao
author_sort Xu, Xintian
collection PubMed
description Uridine, a pyrimidine nucleoside, is crucial in the synthesis of metabolites. According to observational studies, a higher plasma uridine level is associated with a lower risk of atrial fibrillation (AF). However, the casual relationship between uridine and AF is still unknown. In this study, we used the Mendelian randomisation (MR) approach to explore causality. Three genetic variants associated with uridine were identified from the Metabolomics GWAS server (7824 participants); summary-level datasets associated with AF were acquired from a genome-wide association study (GWAS) meta-analysis with 1,030,836 European participants (60,620 AF cases). We duplicated the MR analyses using datasets from AF HRC studies and the FinnGen Consortium, and then conducted a meta-analysis which combined the main results. The risk of AF was significantly associated with the genetically determined plasma uridine level (odds ratio [OR] 0.27; 95% confidence interval [CI] 0.16, 0.47; p = 2.39 × 10(–6)). The association remained consistent in the meta-analysis of the various datasets (OR 0.27; 95% CI 0.17, 0.42; p = 1.34 × 10(–8)). In conclusion, the plasma uridine level is inversely associated with the risk of AF. Raising the plasma uridine level may have prophylactic potential against AF.
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spelling pubmed-106384432023-11-11 Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study Xu, Xintian Zhang, Xiaoyu Cheng, Shiyao Li, Qinglang Chen, Cai Ouyang, Mao Sci Rep Article Uridine, a pyrimidine nucleoside, is crucial in the synthesis of metabolites. According to observational studies, a higher plasma uridine level is associated with a lower risk of atrial fibrillation (AF). However, the casual relationship between uridine and AF is still unknown. In this study, we used the Mendelian randomisation (MR) approach to explore causality. Three genetic variants associated with uridine were identified from the Metabolomics GWAS server (7824 participants); summary-level datasets associated with AF were acquired from a genome-wide association study (GWAS) meta-analysis with 1,030,836 European participants (60,620 AF cases). We duplicated the MR analyses using datasets from AF HRC studies and the FinnGen Consortium, and then conducted a meta-analysis which combined the main results. The risk of AF was significantly associated with the genetically determined plasma uridine level (odds ratio [OR] 0.27; 95% confidence interval [CI] 0.16, 0.47; p = 2.39 × 10(–6)). The association remained consistent in the meta-analysis of the various datasets (OR 0.27; 95% CI 0.17, 0.42; p = 1.34 × 10(–8)). In conclusion, the plasma uridine level is inversely associated with the risk of AF. Raising the plasma uridine level may have prophylactic potential against AF. Nature Publishing Group UK 2023-11-10 /pmc/articles/PMC10638443/ /pubmed/37950049 http://dx.doi.org/10.1038/s41598-023-47025-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Xu, Xintian
Zhang, Xiaoyu
Cheng, Shiyao
Li, Qinglang
Chen, Cai
Ouyang, Mao
Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study
title Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study
title_full Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study
title_fullStr Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study
title_full_unstemmed Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study
title_short Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study
title_sort protective effect of uridine on atrial fibrillation: a mendelian randomisation study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638443/
https://www.ncbi.nlm.nih.gov/pubmed/37950049
http://dx.doi.org/10.1038/s41598-023-47025-8
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