N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes

CircRNAs play multiple roles in a variety of cellular processes. We found that Circ-CDYL is highly enriched in early HCC plasma exosomes. Moreover, EpCAM(+) HCC cells and exosomes had significant Circ-CDYL levels. We postulated that Circ-CDYL-enriched and EpCAM-positive exosomes would function as li...

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Detalles Bibliográficos
Autores principales: Wei, Yanping, Fu, Jingbo, Zhang, Hailing, Ling, Yan, Tang, Xuewu, Liu, Shuowu, Yu, Miao, Liu, Fuyan, Zhuang, Guokun, Qian, Haihua, Zhang, Kecheng, Yang, Pinhua, Yang, Xinwei, Yang, Qi, Ge, Shennian, Zhang, Baohua, Tan, Yexiong, Li, Liang, Wang, Hongyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638478/
https://www.ncbi.nlm.nih.gov/pubmed/37954137
http://dx.doi.org/10.1016/j.isci.2023.108022

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