The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized, less is known about the regulation of PXR protein le...

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Detalles Bibliográficos
Autores principales: Florke Gee, Rebecca R., Huber, Andrew D., Wu, Jing, Bajpai, Richa, Loughran, Allister J., Pruett-Miller, Shondra M., Chen, Taosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638512/
https://www.ncbi.nlm.nih.gov/pubmed/37969738
http://dx.doi.org/10.1016/j.apsb.2023.07.014

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