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CRISPR-mediated genome editing allows for efficient on demand creation of >200 kb deficiencies with precise boundaries.

Deficiency mapping remains a useful tool in the process of identifying causative genetic lesions in C. elegans mutant strains isolated from forward genetic screens, in particular of non-coding mutants. However, there are significant areas across the genome with no deficiency coverage at all, and the...

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Detalles Bibliográficos
Autores principales: Trivedi, Meera, Camara, Lamine J., Bülow, Hannes E., Tang, Leo T. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638593/
https://www.ncbi.nlm.nih.gov/pubmed/37954518
http://dx.doi.org/10.17912/micropub.biology.000949

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