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CRISPR-mediated genome editing allows for efficient on demand creation of >200 kb deficiencies with precise boundaries.
Deficiency mapping remains a useful tool in the process of identifying causative genetic lesions in C. elegans mutant strains isolated from forward genetic screens, in particular of non-coding mutants. However, there are significant areas across the genome with no deficiency coverage at all, and the...
Autores principales: | Trivedi, Meera, Camara, Lamine J., Bülow, Hannes E., Tang, Leo T. H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638593/ https://www.ncbi.nlm.nih.gov/pubmed/37954518 http://dx.doi.org/10.17912/micropub.biology.000949 |
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