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The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics

OBJECTIVE: The persistence of HPV infection is a significant etiological factor in the development of cervical cancer. The present study investigated the prevalence and genotype distribution of human papillomavirus (HPV) in a cohort of 164,137 unvaccinated women from Wenzhou, aiming to provide guida...

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Autores principales: Chen, Qiong, Qu, Wanglei, Zhao, Yu, Shu, Li, Wang, Yi, Chen, Xiangnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638728/
https://www.ncbi.nlm.nih.gov/pubmed/37950328
http://dx.doi.org/10.1186/s13027-023-00553-4
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author Chen, Qiong
Qu, Wanglei
Zhao, Yu
Shu, Li
Wang, Yi
Chen, Xiangnan
author_facet Chen, Qiong
Qu, Wanglei
Zhao, Yu
Shu, Li
Wang, Yi
Chen, Xiangnan
author_sort Chen, Qiong
collection PubMed
description OBJECTIVE: The persistence of HPV infection is a significant etiological factor in the development of cervical cancer. The present study investigated the prevalence and genotype distribution of human papillomavirus (HPV) in a cohort of 164,137 unvaccinated women from Wenzhou, aiming to provide guidance for clinics in the cervical cancer screening and HPV vaccination strategies. METHODS: The present retrospective study included a total of 164,137 women, comprising 118,484 outpatients and 45,653 healthy female subjects recruited from 2015 to 2020. Cervical exfoliated cells were collected from these participants for subsequent DNA extraction. The extracted DNA samples were underwent analysis using a fluorescence in situ hybridization method, encompassing the detection of 27 HPV genotypes. RESULTS: The overall prevalence of HPV was 17.35%; this corresponded to a prevalence of 19.10% in the outpatient group and 12.82% in the healthy female group. Among the outpatient group, the five most prevalent HPV genotypes were identified as HPV 52, 58, 16, 53, and 61. In the healthy female group, the five most common HPV genotypes were found to be HPV 52, 53, 58, 61, and 81. Additionally, it was estimated that the highest rate of HPV infection occurred among individuals aged between 10 and 19 years old (44.65%) and those aged between 60 and 69 years old (27.35%). CONCLUSIONS: The prevalence of HPV in this region is substantial; therefore, it is imperative to implement scientifically sound and rational clinical interventions such as vaccination. Routine cervical screening should be performed to prevent the development of cervical intraepithelial neoplasia resulting from persistent infection with high-risk HPV, particularly in women with gynecological diseases and those over 60 years old. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13027-023-00553-4.
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spelling pubmed-106387282023-11-11 The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics Chen, Qiong Qu, Wanglei Zhao, Yu Shu, Li Wang, Yi Chen, Xiangnan Infect Agent Cancer Research OBJECTIVE: The persistence of HPV infection is a significant etiological factor in the development of cervical cancer. The present study investigated the prevalence and genotype distribution of human papillomavirus (HPV) in a cohort of 164,137 unvaccinated women from Wenzhou, aiming to provide guidance for clinics in the cervical cancer screening and HPV vaccination strategies. METHODS: The present retrospective study included a total of 164,137 women, comprising 118,484 outpatients and 45,653 healthy female subjects recruited from 2015 to 2020. Cervical exfoliated cells were collected from these participants for subsequent DNA extraction. The extracted DNA samples were underwent analysis using a fluorescence in situ hybridization method, encompassing the detection of 27 HPV genotypes. RESULTS: The overall prevalence of HPV was 17.35%; this corresponded to a prevalence of 19.10% in the outpatient group and 12.82% in the healthy female group. Among the outpatient group, the five most prevalent HPV genotypes were identified as HPV 52, 58, 16, 53, and 61. In the healthy female group, the five most common HPV genotypes were found to be HPV 52, 53, 58, 61, and 81. Additionally, it was estimated that the highest rate of HPV infection occurred among individuals aged between 10 and 19 years old (44.65%) and those aged between 60 and 69 years old (27.35%). CONCLUSIONS: The prevalence of HPV in this region is substantial; therefore, it is imperative to implement scientifically sound and rational clinical interventions such as vaccination. Routine cervical screening should be performed to prevent the development of cervical intraepithelial neoplasia resulting from persistent infection with high-risk HPV, particularly in women with gynecological diseases and those over 60 years old. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13027-023-00553-4. BioMed Central 2023-11-10 /pmc/articles/PMC10638728/ /pubmed/37950328 http://dx.doi.org/10.1186/s13027-023-00553-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Qiong
Qu, Wanglei
Zhao, Yu
Shu, Li
Wang, Yi
Chen, Xiangnan
The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics
title The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics
title_full The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics
title_fullStr The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics
title_full_unstemmed The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics
title_short The prevalence of HPV among 164,137 women in China exhibited some unique epidemiological characteristics
title_sort prevalence of hpv among 164,137 women in china exhibited some unique epidemiological characteristics
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638728/
https://www.ncbi.nlm.nih.gov/pubmed/37950328
http://dx.doi.org/10.1186/s13027-023-00553-4
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