The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair

Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials. Through genetic engineering, biomaterials prepared from ELPs can have...

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Autores principales: Guo, Yingshu, Liu, Shiwei, Jing, Dan, Liu, Nianzu, Luo, Xiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638729/
https://www.ncbi.nlm.nih.gov/pubmed/37951928
http://dx.doi.org/10.1186/s12951-023-02184-8
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author Guo, Yingshu
Liu, Shiwei
Jing, Dan
Liu, Nianzu
Luo, Xiliang
author_facet Guo, Yingshu
Liu, Shiwei
Jing, Dan
Liu, Nianzu
Luo, Xiliang
author_sort Guo, Yingshu
collection PubMed
description Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials. Through genetic engineering, biomaterials prepared from ELPs can have unique and customizable properties. By adjusting the amino acid sequence and length of ELPs, nanostructures, such as micelles and nanofibers, can be formed. Correspondingly, ELPs have been used for improving the stability and prolonging drug-release time. Furthermore, ELPs have widespread use in tissue repair due to their biocompatibility and biodegradability. Here, this review summarizes the basic property composition of ELPs and the methods for modulating their phase transition properties, discusses the application of drug delivery system and tissue repair and clarifies the current challenges and future directions of ELPs in applications.
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spelling pubmed-106387292023-11-11 The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair Guo, Yingshu Liu, Shiwei Jing, Dan Liu, Nianzu Luo, Xiliang J Nanobiotechnology Review Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials. Through genetic engineering, biomaterials prepared from ELPs can have unique and customizable properties. By adjusting the amino acid sequence and length of ELPs, nanostructures, such as micelles and nanofibers, can be formed. Correspondingly, ELPs have been used for improving the stability and prolonging drug-release time. Furthermore, ELPs have widespread use in tissue repair due to their biocompatibility and biodegradability. Here, this review summarizes the basic property composition of ELPs and the methods for modulating their phase transition properties, discusses the application of drug delivery system and tissue repair and clarifies the current challenges and future directions of ELPs in applications. BioMed Central 2023-11-11 /pmc/articles/PMC10638729/ /pubmed/37951928 http://dx.doi.org/10.1186/s12951-023-02184-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Guo, Yingshu
Liu, Shiwei
Jing, Dan
Liu, Nianzu
Luo, Xiliang
The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
title The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
title_full The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
title_fullStr The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
title_full_unstemmed The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
title_short The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
title_sort construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638729/
https://www.ncbi.nlm.nih.gov/pubmed/37951928
http://dx.doi.org/10.1186/s12951-023-02184-8
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