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The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review

BACKGROUND: Malaria is a life-threatening disease prevalent in tropical and subtropical regions. Artemisinin combination therapy (ACT) used as an antimalarial treatment has reduced efficacy due to resistance, not only to the parasite but also to the vector. Therefore, it is important to find alterna...

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Autores principales: Kusman, Irfan Taufik, Pradini, Gita Widya, Ma’ruf, Ilma Fauziah, Fauziah, Nisa, Berbudi, Afiat, Achadiyani, Achadiyani, Wiraswati, Hesti Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638911/
https://www.ncbi.nlm.nih.gov/pubmed/37954507
http://dx.doi.org/10.2147/IDR.S433328
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author Kusman, Irfan Taufik
Pradini, Gita Widya
Ma’ruf, Ilma Fauziah
Fauziah, Nisa
Berbudi, Afiat
Achadiyani, Achadiyani
Wiraswati, Hesti Lina
author_facet Kusman, Irfan Taufik
Pradini, Gita Widya
Ma’ruf, Ilma Fauziah
Fauziah, Nisa
Berbudi, Afiat
Achadiyani, Achadiyani
Wiraswati, Hesti Lina
author_sort Kusman, Irfan Taufik
collection PubMed
description BACKGROUND: Malaria is a life-threatening disease prevalent in tropical and subtropical regions. Artemisinin combination therapy (ACT) used as an antimalarial treatment has reduced efficacy due to resistance, not only to the parasite but also to the vector. Therefore, it is important to find alternatives to overcome malaria cases through medicinal plants such as Ageratum conyzoides and other related plants within Asteraceae family. PURPOSE: This review summarizes the antimalarial and insecticidal activities of A. conyzoides and other plants belonging to Asteraceae family. DATA SOURCE: Google Scholar, PubMed, Science Direct, and Springer link. STUDY SELECTION: Online databases were used to retrieve journals using specific keywords combined with Boolean operators. The inclusion criteria were articles with experimental studies either in vivo or in vitro, in English or Indonesian, published after 1st January 2000, and full text available for inclusion in this review. DATA EXTRACTION: The antimalarial activity, insecticidal activity, and structure of the isolated compounds were retrieved from the selected studies. DATA SYNTHESIS: Antimalarial in vitro study showed that the dichloromethane extract was the most widely studied with an IC50 value <10 μg/mL. Among 84 isolated active compounds, 2-hydroxymethyl-non-3-ynoic acid 2-[2,2’]-bithiophenyl-5- ethyl ester, a bithienyl compound from the Tagetes erecta plant show the smallest IC50 with value 0.01 and 0.02 µg/mL in Plasmodium falciparum MRC-pf-2 and MRC-pf-56, respectively. In vivo studies showed that the aqueous extract of A. conyzoides showed the best activity, with a 98.8% inhibition percentage using a 100 mg/kg dose of Plasmodium berghei (NK65 Strain). (Z)- γ-Bisabolene from Galinsoga parviflora showed very good insecticidal activity against Anopheles stephensi and Anopheles subpictus with LC50 values of 2.04 μg/mL and 4.05 μg/mL. CONCLUSION: A. conyzoides and other plants of Asteraceae family are promising reservoirs of natural compounds that exert antimalarial or insecticidal activity.
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spelling pubmed-106389112023-11-11 The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review Kusman, Irfan Taufik Pradini, Gita Widya Ma’ruf, Ilma Fauziah Fauziah, Nisa Berbudi, Afiat Achadiyani, Achadiyani Wiraswati, Hesti Lina Infect Drug Resist Review BACKGROUND: Malaria is a life-threatening disease prevalent in tropical and subtropical regions. Artemisinin combination therapy (ACT) used as an antimalarial treatment has reduced efficacy due to resistance, not only to the parasite but also to the vector. Therefore, it is important to find alternatives to overcome malaria cases through medicinal plants such as Ageratum conyzoides and other related plants within Asteraceae family. PURPOSE: This review summarizes the antimalarial and insecticidal activities of A. conyzoides and other plants belonging to Asteraceae family. DATA SOURCE: Google Scholar, PubMed, Science Direct, and Springer link. STUDY SELECTION: Online databases were used to retrieve journals using specific keywords combined with Boolean operators. The inclusion criteria were articles with experimental studies either in vivo or in vitro, in English or Indonesian, published after 1st January 2000, and full text available for inclusion in this review. DATA EXTRACTION: The antimalarial activity, insecticidal activity, and structure of the isolated compounds were retrieved from the selected studies. DATA SYNTHESIS: Antimalarial in vitro study showed that the dichloromethane extract was the most widely studied with an IC50 value <10 μg/mL. Among 84 isolated active compounds, 2-hydroxymethyl-non-3-ynoic acid 2-[2,2’]-bithiophenyl-5- ethyl ester, a bithienyl compound from the Tagetes erecta plant show the smallest IC50 with value 0.01 and 0.02 µg/mL in Plasmodium falciparum MRC-pf-2 and MRC-pf-56, respectively. In vivo studies showed that the aqueous extract of A. conyzoides showed the best activity, with a 98.8% inhibition percentage using a 100 mg/kg dose of Plasmodium berghei (NK65 Strain). (Z)- γ-Bisabolene from Galinsoga parviflora showed very good insecticidal activity against Anopheles stephensi and Anopheles subpictus with LC50 values of 2.04 μg/mL and 4.05 μg/mL. CONCLUSION: A. conyzoides and other plants of Asteraceae family are promising reservoirs of natural compounds that exert antimalarial or insecticidal activity. Dove 2023-11-07 /pmc/articles/PMC10638911/ /pubmed/37954507 http://dx.doi.org/10.2147/IDR.S433328 Text en © 2023 Kusman et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Kusman, Irfan Taufik
Pradini, Gita Widya
Ma’ruf, Ilma Fauziah
Fauziah, Nisa
Berbudi, Afiat
Achadiyani, Achadiyani
Wiraswati, Hesti Lina
The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review
title The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review
title_full The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review
title_fullStr The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review
title_full_unstemmed The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review
title_short The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review
title_sort potentials of ageratum conyzoides and other plants from asteraceae as an antiplasmodial and insecticidal for malaria vector: an article review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638911/
https://www.ncbi.nlm.nih.gov/pubmed/37954507
http://dx.doi.org/10.2147/IDR.S433328
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