Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans

DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrometry-based adductomics (LC–MS/MS) to begin to define the lands...

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Detalles Bibliográficos
Autores principales: Guilbaud, Axel, Ghanegolmohammadi, Farzan, Wang, Yijun, Leng, Jiapeng, Kreymerman, Alexander, Gamboa Varela, Jacqueline, Garbern, Jessica, Elwell, Hannah, Cao, Fang, Ricci-Blair, Elisabeth M, Liang, Cui, Balamkundu, Seetharamsing, Vidoudez, Charles, DeMott, Michael S, Bedi, Kenneth, Margulies, Kenneth B, Bennett, David A, Palmer, Abraham A, Barkley-Levenson, Amanda, Lee, Richard T, Dedon, Peter C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639045/
https://www.ncbi.nlm.nih.gov/pubmed/37843128
http://dx.doi.org/10.1093/nar/gkad822

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