Cargando…

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance

Zinc finger (ZNF) motifs are some of the most frequently occurring domains in the human genome. It was only recently that ZNF proteins emerged as key regulators of genome integrity in mammalian cells. In this study, we report a new role for the Krüppel-type ZNF-containing protein ZNF432 as a novel p...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Sullivan, Julia, Kothari, Charu, Caron, Marie-Christine, Gagné, Jean-Philippe, Jin, Zhigang, Nonfoux, Louis, Beneyton, Adèle, Coulombe, Yan, Thomas, Mélissa, Atalay, Nurgul, Meng, X Wei, Milano, Larissa, Jean, Dominique, Boisvert, François-Michel, Kaufmann, Scott H, Hendzel, Michael J, Masson, Jean-Yves, Poirier, Guy G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639050/ https://www.ncbi.nlm.nih.gov/pubmed/37823600 http://dx.doi.org/10.1093/nar/gkad791

Ejemplares similares

The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors
por: Beneyton, Adèle, et al.
Publicado: (2023)

CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage
por: Ismail, Ismail Hassan, et al.
Publicado: (2012)

PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks
por: Krietsch, Jana, et al.
Publicado: (2012)

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1
por: Liu, Lili, et al.
Publicado: (2017)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection
por: Batenburg, Nicole L, et al.
Publicado: (2019)

Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2012)

The identification of FANCD2 DNA binding domains reveals nuclear localization sequences
por: Niraj, Joshi, et al.
Publicado: (2017)

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2015)

Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells
por: Batenburg, Nicole L, et al.
Publicado: (2021)

ZNF212 promotes genomic integrity through direct interaction with TRAIP
por: Chung, Hee Jin, et al.
Publicado: (2023)

ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair
por: Chen, Guo, et al.
Publicado: (2018)

A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor
por: Rodrigue, Amélie, et al.
Publicado: (2019)

PALB2 self-interaction controls homologous recombination
por: Buisson, Rémi, et al.
Publicado: (2012)

Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress
por: Gagné, Jean-Philippe, et al.
Publicado: (2012)

PARP1 associates with R-loops to promote their resolution and genome stability
por: Laspata, Natalie, et al.
Publicado: (2023)

PARPi after PARPi in epithelial ovarian cancer
por: Essel, K.G., et al.
Publicado: (2021)

SUMOylation mediates CtIP’s functions in DNA end resection and replication fork protection
por: Locke, Andrew J, et al.
Publicado: (2021)

PIP degron proteins, substrates of CRL4(Cdt2), and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage
por: Tsanov, Nikolay, et al.
Publicado: (2014)

RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function
por: So, Ayeong, et al.
Publicado: (2022)

ZNF768 links oncogenic RAS to cellular senescence
por: Villot, Romain, et al.
Publicado: (2021)

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing
por: Carvajal-Maldonado, Denisse, et al.
Publicado: (2019)

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
por: Liu, Wenpeng, et al.
Publicado: (2023)

Origin-dependent initiation of DNA replication within telomeric sequences
por: Kurth, Isabel, et al.
Publicado: (2010)

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage
por: Zolner, Angela E., et al.
Publicado: (2011)

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets
por: Krastev, Dragomir B., et al.
Publicado: (2018)

Human telomeres that contain (CTAGGG)(n) repeats show replication dependent instability in somatic cells and the male germline
por: Mendez-Bermudez, Aaron, et al.
Publicado: (2009)

A DNA break inducer activates the anticodon nuclease RloC and the adaptive immunity in Acinetobacter baylyi ADP1
por: Klaiman, Daniel, et al.
Publicado: (2014)

XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase
por: Sharma, Abhishek Bharadwaj, et al.
Publicado: (2021)

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1
por: Calkins, Anne S., et al.
Publicado: (2013)

ATP-dependent nucleosome unwrapping catalyzed by human RAD51
por: North, Justin A., et al.
Publicado: (2013)

Insight into centromere-binding properties of ParB proteins: a secondary binding motif is essential for bacterial genome maintenance
por: Sanchez, Aurore, et al.
Publicado: (2013)

To PARPI or Not to PARPI BRCA Mutated Ovarian Cancer Following First-line Chemotherapy, That is the Question?
por: Rose, Peter G, et al.
Publicado: (2021)

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
por: Mortusewicz, Oliver, et al.
Publicado: (2011)

Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells
por: Covo, Shay, et al.
Publicado: (2009)

Two pathways drive meiotic chromosome axis assembly in Saccharomyces cerevisiae
por: Heldrich, Jonna, et al.
Publicado: (2022)

Centromere binding specificity in assembly of the F plasmid partition complex
por: Pillet, Flavien, et al.
Publicado: (2011)

Interaction of human telomeric DNA with N-methyl mesoporphyrin IX
por: Nicoludis, John M., et al.
Publicado: (2012)

Replication dynamics of individual loci in single living cells reveal changes in the degree of replication stochasticity through S phase
por: Duriez, Bénédicte, et al.
Publicado: (2019)

A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage
por: Cappadocia, Laurent, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_f0b13l3uid3kicl2b777aod2nm