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Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics

We have developed RHINO, a genetically encoded sensor that selectively binds RNA:DNA hybrids enabling live-cell imaging of cellular R-loops. RHINO comprises a tandem array of three copies of the RNA:DNA hybrid binding domain of human RNase H1 connected by optimized linker segments and fused to a flu...

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Detalles Bibliográficos
Autores principales:	Martin, Robert M, de Almeida, Madalena R, Gameiro, Eduardo, de Almeida, Sérgio F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639055/ https://www.ncbi.nlm.nih.gov/pubmed/37819055 http://dx.doi.org/10.1093/nar/gkad812

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