Engineering of cytosine base editors with DNA damage minimization and editing scope diversification

Cytosine base editors (CBEs), which enable precise C-to-T substitutions, have been restricted by potential safety risks, including DNA off-target edits, RNA off-target edits and additional genotoxicity such as DNA damages induced by double-strand breaks (DSBs). Though DNA and RNA off-target edits ha...

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Detalles Bibliográficos
Autores principales: Yuan, Bo, Zhang, Shuqian, Song, Liting, Chen, Jinlong, Cao, Jixin, Qiu, Jiayi, Qiu, Zilong, Chen, Jingqi, Zhao, Xing-Ming, Cheng, Tian-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639057/
https://www.ncbi.nlm.nih.gov/pubmed/37843111
http://dx.doi.org/10.1093/nar/gkad855

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