Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility

MicroRNAs (miRNAs) are short RNAs that post-transcriptionally regulate gene expression by binding to specific sites in mRNAs. Site recognition is primarily mediated by the seed region (nucleotides g2–g8 in the miRNA), but pairing beyond the seed (3′-pairing) is important for some miRNA:target intera...

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Detalles Bibliográficos
Autores principales: Kosek, David M, Banijamali, Elnaz, Becker, Walter, Petzold, Katja, Andersson, Emma R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639062/
https://www.ncbi.nlm.nih.gov/pubmed/37819016
http://dx.doi.org/10.1093/nar/gkad795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639062/
https://www.ncbi.nlm.nih.gov/pubmed/37819016
http://dx.doi.org/10.1093/nar/gkad795

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