DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis

DNA mismatch repair (MMR) corrects mismatched DNA bases arising from multiple sources including polymerase errors and base damage. By detecting spontaneous mutagenesis using whole genome sequencing of cultured MMR deficient human cell lines, we show that a primary role of MMR is the repair of oxygen...

Descripción completa

Detalles Bibliográficos
Autores principales: Lózsa, Rita, Németh, Eszter, Gervai, Judit Z, Márkus, Bence G, Kollarics, Sándor, Gyüre, Zsolt, Tóth, Judit, Simon, Ferenc, Szüts, Dávid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639081/
https://www.ncbi.nlm.nih.gov/pubmed/37791890
http://dx.doi.org/10.1093/nar/gkad775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639081/
https://www.ncbi.nlm.nih.gov/pubmed/37791890
http://dx.doi.org/10.1093/nar/gkad775

Ejemplares similares