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The emerging role of oral microbiota in oral cancer initiation, progression and stemness
Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive tumors. Recent sequencing based studies demonstrated the involvement of different oral microbiota in oral cavity diseases leading OSC...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639169/ https://www.ncbi.nlm.nih.gov/pubmed/37954619 http://dx.doi.org/10.3389/fimmu.2023.1198269 |
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author | Saikia, Partha Jyoti Pathak, Lekhika Mitra, Shirsajit Das, Bikul |
author_facet | Saikia, Partha Jyoti Pathak, Lekhika Mitra, Shirsajit Das, Bikul |
author_sort | Saikia, Partha Jyoti |
collection | PubMed |
description | Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive tumors. Recent sequencing based studies demonstrated the involvement of different oral microbiota in oral cavity diseases leading OSCC carcinogenesis, initiation and progression. Researches showed that oral microbiota can activate different inflammatory pathways and cancer stem cells (CSCs) associated stemness pathways for tumor progression. We speculate that CSCs and their niche cells may interact with the microbiotas to promote tumor progression and stemness. Certain oral microbiotas are reported to be involved in dysbiosis, pre-cancerous lesions, and OSCC development. Identification of these specific microbiota including Human papillomavirus (HPV), Porphyromonas gingivalis (PG), and Fusobacterium nucleatum (FN) provides us with a new opportunity to study the bacteria/stem cell, as well as bacteria/OSCC cells interaction that promote OSCC initiation, progression and stemness. Importantly, these evidences enabled us to develop in-vitro and in-vivo models to study microbiota interaction with stem cell niche defense as well as CSC niche defense. Thus in this review, the role of oral microbiota in OSCC has been explored with a special focus on how oral microbiota induces OSCC initiation and stemness by modulating the oral mucosal stem cell and CSC niche defense. |
format | Online Article Text |
id | pubmed-10639169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106391692023-11-11 The emerging role of oral microbiota in oral cancer initiation, progression and stemness Saikia, Partha Jyoti Pathak, Lekhika Mitra, Shirsajit Das, Bikul Front Immunol Immunology Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive tumors. Recent sequencing based studies demonstrated the involvement of different oral microbiota in oral cavity diseases leading OSCC carcinogenesis, initiation and progression. Researches showed that oral microbiota can activate different inflammatory pathways and cancer stem cells (CSCs) associated stemness pathways for tumor progression. We speculate that CSCs and their niche cells may interact with the microbiotas to promote tumor progression and stemness. Certain oral microbiotas are reported to be involved in dysbiosis, pre-cancerous lesions, and OSCC development. Identification of these specific microbiota including Human papillomavirus (HPV), Porphyromonas gingivalis (PG), and Fusobacterium nucleatum (FN) provides us with a new opportunity to study the bacteria/stem cell, as well as bacteria/OSCC cells interaction that promote OSCC initiation, progression and stemness. Importantly, these evidences enabled us to develop in-vitro and in-vivo models to study microbiota interaction with stem cell niche defense as well as CSC niche defense. Thus in this review, the role of oral microbiota in OSCC has been explored with a special focus on how oral microbiota induces OSCC initiation and stemness by modulating the oral mucosal stem cell and CSC niche defense. Frontiers Media S.A. 2023-10-26 /pmc/articles/PMC10639169/ /pubmed/37954619 http://dx.doi.org/10.3389/fimmu.2023.1198269 Text en Copyright © 2023 Saikia, Pathak, Mitra and Das https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Saikia, Partha Jyoti Pathak, Lekhika Mitra, Shirsajit Das, Bikul The emerging role of oral microbiota in oral cancer initiation, progression and stemness |
title | The emerging role of oral microbiota in oral cancer initiation, progression and stemness |
title_full | The emerging role of oral microbiota in oral cancer initiation, progression and stemness |
title_fullStr | The emerging role of oral microbiota in oral cancer initiation, progression and stemness |
title_full_unstemmed | The emerging role of oral microbiota in oral cancer initiation, progression and stemness |
title_short | The emerging role of oral microbiota in oral cancer initiation, progression and stemness |
title_sort | emerging role of oral microbiota in oral cancer initiation, progression and stemness |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10639169/ https://www.ncbi.nlm.nih.gov/pubmed/37954619 http://dx.doi.org/10.3389/fimmu.2023.1198269 |
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