Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use

Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department’s base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic hematopoietic stem cell transplantation after receiving a...

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Autores principales: Kovacsova, Flora, Folber, Frantisek, Weinbergerova, Barbora, Stepanova, Radka, Kabut, Tomas, Tomiska, Miroslav, Krejci, Marta, Mayer, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640449/
https://www.ncbi.nlm.nih.gov/pubmed/37783854
http://dx.doi.org/10.1007/s00277-023-05479-w
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author Kovacsova, Flora
Folber, Frantisek
Weinbergerova, Barbora
Stepanova, Radka
Kabut, Tomas
Tomiska, Miroslav
Krejci, Marta
Mayer, Jiri
author_facet Kovacsova, Flora
Folber, Frantisek
Weinbergerova, Barbora
Stepanova, Radka
Kabut, Tomas
Tomiska, Miroslav
Krejci, Marta
Mayer, Jiri
author_sort Kovacsova, Flora
collection PubMed
description Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department’s base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic hematopoietic stem cell transplantation after receiving a defined dose of ATG Grafalon. Our observations recorded reduced incidence of severe acute and chronic GVHD without negative impact on overall survival in a nonselected group with standard and uniform GVHD prophylaxis.
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spelling pubmed-106404492023-11-14 Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use Kovacsova, Flora Folber, Frantisek Weinbergerova, Barbora Stepanova, Radka Kabut, Tomas Tomiska, Miroslav Krejci, Marta Mayer, Jiri Ann Hematol Original Article Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department’s base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic hematopoietic stem cell transplantation after receiving a defined dose of ATG Grafalon. Our observations recorded reduced incidence of severe acute and chronic GVHD without negative impact on overall survival in a nonselected group with standard and uniform GVHD prophylaxis. Springer Berlin Heidelberg 2023-10-03 2023 /pmc/articles/PMC10640449/ /pubmed/37783854 http://dx.doi.org/10.1007/s00277-023-05479-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Kovacsova, Flora
Folber, Frantisek
Weinbergerova, Barbora
Stepanova, Radka
Kabut, Tomas
Tomiska, Miroslav
Krejci, Marta
Mayer, Jiri
Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
title Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
title_full Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
title_fullStr Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
title_full_unstemmed Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
title_short Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
title_sort low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with atg grafalon routine use
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640449/
https://www.ncbi.nlm.nih.gov/pubmed/37783854
http://dx.doi.org/10.1007/s00277-023-05479-w
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