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The nuclear entry of the aryl hydrocarbon receptor (AHR) relies on the first nuclear localization signal and can be negatively regulated through IMPα/β specific inhibitors

The human aryl hydrocarbon receptor (AHR) undergoes continuous shuttling between nucleus and cytoplasm. Binding to exogenous or endogenous ligands promotes its rapid nuclear import. The proposed mechanism for the ligand-dependent import is based on exposing the bipartite nuclear localisation signal...

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Detalles Bibliográficos
Autores principales:	Haidar, Rashad, Shabo, Reneh, Moeser, Marie, Luch, Andreas, Kugler, Josephine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640566/ https://www.ncbi.nlm.nih.gov/pubmed/37951956 http://dx.doi.org/10.1038/s41598-023-47066-z

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