Cargando…

An on-demand bioresorbable neurostimulator

Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy soluti...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Dong-Min, Kang, Minki, Hyun, Inah, Park, Byung-Joon, Kim, Hye Jin, Nam, Soo Hyun, Yoon, Hong-Joon, Ryu, Hanjun, Park, Hyun-moon, Choi, Byung-Ok, Kim, Sang-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640647/
https://www.ncbi.nlm.nih.gov/pubmed/37951985
http://dx.doi.org/10.1038/s41467-023-42791-5
_version_ 1785133802751787008
author Lee, Dong-Min
Kang, Minki
Hyun, Inah
Park, Byung-Joon
Kim, Hye Jin
Nam, Soo Hyun
Yoon, Hong-Joon
Ryu, Hanjun
Park, Hyun-moon
Choi, Byung-Ok
Kim, Sang-Woo
author_facet Lee, Dong-Min
Kang, Minki
Hyun, Inah
Park, Byung-Joon
Kim, Hye Jin
Nam, Soo Hyun
Yoon, Hong-Joon
Ryu, Hanjun
Park, Hyun-moon
Choi, Byung-Ok
Kim, Sang-Woo
author_sort Lee, Dong-Min
collection PubMed
description Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy.
format Online
Article
Text
id pubmed-10640647
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-106406472023-11-11 An on-demand bioresorbable neurostimulator Lee, Dong-Min Kang, Minki Hyun, Inah Park, Byung-Joon Kim, Hye Jin Nam, Soo Hyun Yoon, Hong-Joon Ryu, Hanjun Park, Hyun-moon Choi, Byung-Ok Kim, Sang-Woo Nat Commun Article Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy. Nature Publishing Group UK 2023-11-11 /pmc/articles/PMC10640647/ /pubmed/37951985 http://dx.doi.org/10.1038/s41467-023-42791-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lee, Dong-Min
Kang, Minki
Hyun, Inah
Park, Byung-Joon
Kim, Hye Jin
Nam, Soo Hyun
Yoon, Hong-Joon
Ryu, Hanjun
Park, Hyun-moon
Choi, Byung-Ok
Kim, Sang-Woo
An on-demand bioresorbable neurostimulator
title An on-demand bioresorbable neurostimulator
title_full An on-demand bioresorbable neurostimulator
title_fullStr An on-demand bioresorbable neurostimulator
title_full_unstemmed An on-demand bioresorbable neurostimulator
title_short An on-demand bioresorbable neurostimulator
title_sort on-demand bioresorbable neurostimulator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640647/
https://www.ncbi.nlm.nih.gov/pubmed/37951985
http://dx.doi.org/10.1038/s41467-023-42791-5
work_keys_str_mv AT leedongmin anondemandbioresorbableneurostimulator
AT kangminki anondemandbioresorbableneurostimulator
AT hyuninah anondemandbioresorbableneurostimulator
AT parkbyungjoon anondemandbioresorbableneurostimulator
AT kimhyejin anondemandbioresorbableneurostimulator
AT namsoohyun anondemandbioresorbableneurostimulator
AT yoonhongjoon anondemandbioresorbableneurostimulator
AT ryuhanjun anondemandbioresorbableneurostimulator
AT parkhyunmoon anondemandbioresorbableneurostimulator
AT choibyungok anondemandbioresorbableneurostimulator
AT kimsangwoo anondemandbioresorbableneurostimulator
AT leedongmin ondemandbioresorbableneurostimulator
AT kangminki ondemandbioresorbableneurostimulator
AT hyuninah ondemandbioresorbableneurostimulator
AT parkbyungjoon ondemandbioresorbableneurostimulator
AT kimhyejin ondemandbioresorbableneurostimulator
AT namsoohyun ondemandbioresorbableneurostimulator
AT yoonhongjoon ondemandbioresorbableneurostimulator
AT ryuhanjun ondemandbioresorbableneurostimulator
AT parkhyunmoon ondemandbioresorbableneurostimulator
AT choibyungok ondemandbioresorbableneurostimulator
AT kimsangwoo ondemandbioresorbableneurostimulator