Cargando…
An on-demand bioresorbable neurostimulator
Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy soluti...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640647/ https://www.ncbi.nlm.nih.gov/pubmed/37951985 http://dx.doi.org/10.1038/s41467-023-42791-5 |
_version_ | 1785133802751787008 |
---|---|
author | Lee, Dong-Min Kang, Minki Hyun, Inah Park, Byung-Joon Kim, Hye Jin Nam, Soo Hyun Yoon, Hong-Joon Ryu, Hanjun Park, Hyun-moon Choi, Byung-Ok Kim, Sang-Woo |
author_facet | Lee, Dong-Min Kang, Minki Hyun, Inah Park, Byung-Joon Kim, Hye Jin Nam, Soo Hyun Yoon, Hong-Joon Ryu, Hanjun Park, Hyun-moon Choi, Byung-Ok Kim, Sang-Woo |
author_sort | Lee, Dong-Min |
collection | PubMed |
description | Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy. |
format | Online Article Text |
id | pubmed-10640647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106406472023-11-11 An on-demand bioresorbable neurostimulator Lee, Dong-Min Kang, Minki Hyun, Inah Park, Byung-Joon Kim, Hye Jin Nam, Soo Hyun Yoon, Hong-Joon Ryu, Hanjun Park, Hyun-moon Choi, Byung-Ok Kim, Sang-Woo Nat Commun Article Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy. Nature Publishing Group UK 2023-11-11 /pmc/articles/PMC10640647/ /pubmed/37951985 http://dx.doi.org/10.1038/s41467-023-42791-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lee, Dong-Min Kang, Minki Hyun, Inah Park, Byung-Joon Kim, Hye Jin Nam, Soo Hyun Yoon, Hong-Joon Ryu, Hanjun Park, Hyun-moon Choi, Byung-Ok Kim, Sang-Woo An on-demand bioresorbable neurostimulator |
title | An on-demand bioresorbable neurostimulator |
title_full | An on-demand bioresorbable neurostimulator |
title_fullStr | An on-demand bioresorbable neurostimulator |
title_full_unstemmed | An on-demand bioresorbable neurostimulator |
title_short | An on-demand bioresorbable neurostimulator |
title_sort | on-demand bioresorbable neurostimulator |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640647/ https://www.ncbi.nlm.nih.gov/pubmed/37951985 http://dx.doi.org/10.1038/s41467-023-42791-5 |
work_keys_str_mv | AT leedongmin anondemandbioresorbableneurostimulator AT kangminki anondemandbioresorbableneurostimulator AT hyuninah anondemandbioresorbableneurostimulator AT parkbyungjoon anondemandbioresorbableneurostimulator AT kimhyejin anondemandbioresorbableneurostimulator AT namsoohyun anondemandbioresorbableneurostimulator AT yoonhongjoon anondemandbioresorbableneurostimulator AT ryuhanjun anondemandbioresorbableneurostimulator AT parkhyunmoon anondemandbioresorbableneurostimulator AT choibyungok anondemandbioresorbableneurostimulator AT kimsangwoo anondemandbioresorbableneurostimulator AT leedongmin ondemandbioresorbableneurostimulator AT kangminki ondemandbioresorbableneurostimulator AT hyuninah ondemandbioresorbableneurostimulator AT parkbyungjoon ondemandbioresorbableneurostimulator AT kimhyejin ondemandbioresorbableneurostimulator AT namsoohyun ondemandbioresorbableneurostimulator AT yoonhongjoon ondemandbioresorbableneurostimulator AT ryuhanjun ondemandbioresorbableneurostimulator AT parkhyunmoon ondemandbioresorbableneurostimulator AT choibyungok ondemandbioresorbableneurostimulator AT kimsangwoo ondemandbioresorbableneurostimulator |