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Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering
Recent developments in sequencing technology and analytical approaches have allowed researchers to show that the healthy gut microbiome is very varied and capable of performing a wide range of tasks. The importance of gut microbiota in controlling immunological, neurological, and endocrine function...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640760/ https://www.ncbi.nlm.nih.gov/pubmed/37951913 http://dx.doi.org/10.1186/s12935-023-03095-2 |
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author | Mousavinasab, Fatemehsadat karimi, Ronika Taheri, Sima Ahmadvand, Fatemeh Sanaaee, Saameh Najafi, Sajad Halvaii, Masood Soltani Haghgoo, Alireza Zamany, Marzieh Majidpoor, Jamal Khosravifar, Mina Baniasadi, Mohammad Talebi, Mehrdad Movafagh, Abolfazl Aghaei-Zarch, Seyed Mohsen Khorram, Nastaran Farnia, Poopak Kalhor, Kambiz |
author_facet | Mousavinasab, Fatemehsadat karimi, Ronika Taheri, Sima Ahmadvand, Fatemeh Sanaaee, Saameh Najafi, Sajad Halvaii, Masood Soltani Haghgoo, Alireza Zamany, Marzieh Majidpoor, Jamal Khosravifar, Mina Baniasadi, Mohammad Talebi, Mehrdad Movafagh, Abolfazl Aghaei-Zarch, Seyed Mohsen Khorram, Nastaran Farnia, Poopak Kalhor, Kambiz |
author_sort | Mousavinasab, Fatemehsadat |
collection | PubMed |
description | Recent developments in sequencing technology and analytical approaches have allowed researchers to show that the healthy gut microbiome is very varied and capable of performing a wide range of tasks. The importance of gut microbiota in controlling immunological, neurological, and endocrine function is becoming well-recognized. Thereby, numerous inflammatory diseases, including those that impact the gastrointestinal system, as well as less obvious ones, including Rheumatoid arthritis (RA), cancer, gestational diabetes (GD), type 1 diabetes (T1D), and type 2 diabetes (T2D), have been linked to dysbiotic gut microbiota. Microbiome engineering is a rapidly evolving frontier for solutions to improve human health. Microbiome engineering seeks to improve the function of an ecosystem by manipulating the composition of microbes. Thereby, generating potential therapies against metabolic, inflammatory, and immunological diseases will be possible through microbiome engineering. This essay first provides an overview of the traditional technological instruments that might be used for microbiome engineering, such as Fecal Microbiota Transplantation (FMT), prebiotics, and probiotics. Moreover, we will also discuss experimental genetic methods such as Metagenomic Alteration of Gut microbiome by In situ Conjugation (MAGIC), Bacteriophage, and Conjugative plasmids in manipulating intestinal microbiota. |
format | Online Article Text |
id | pubmed-10640760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106407602023-11-11 Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering Mousavinasab, Fatemehsadat karimi, Ronika Taheri, Sima Ahmadvand, Fatemeh Sanaaee, Saameh Najafi, Sajad Halvaii, Masood Soltani Haghgoo, Alireza Zamany, Marzieh Majidpoor, Jamal Khosravifar, Mina Baniasadi, Mohammad Talebi, Mehrdad Movafagh, Abolfazl Aghaei-Zarch, Seyed Mohsen Khorram, Nastaran Farnia, Poopak Kalhor, Kambiz Cancer Cell Int Review Recent developments in sequencing technology and analytical approaches have allowed researchers to show that the healthy gut microbiome is very varied and capable of performing a wide range of tasks. The importance of gut microbiota in controlling immunological, neurological, and endocrine function is becoming well-recognized. Thereby, numerous inflammatory diseases, including those that impact the gastrointestinal system, as well as less obvious ones, including Rheumatoid arthritis (RA), cancer, gestational diabetes (GD), type 1 diabetes (T1D), and type 2 diabetes (T2D), have been linked to dysbiotic gut microbiota. Microbiome engineering is a rapidly evolving frontier for solutions to improve human health. Microbiome engineering seeks to improve the function of an ecosystem by manipulating the composition of microbes. Thereby, generating potential therapies against metabolic, inflammatory, and immunological diseases will be possible through microbiome engineering. This essay first provides an overview of the traditional technological instruments that might be used for microbiome engineering, such as Fecal Microbiota Transplantation (FMT), prebiotics, and probiotics. Moreover, we will also discuss experimental genetic methods such as Metagenomic Alteration of Gut microbiome by In situ Conjugation (MAGIC), Bacteriophage, and Conjugative plasmids in manipulating intestinal microbiota. BioMed Central 2023-11-11 /pmc/articles/PMC10640760/ /pubmed/37951913 http://dx.doi.org/10.1186/s12935-023-03095-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Mousavinasab, Fatemehsadat karimi, Ronika Taheri, Sima Ahmadvand, Fatemeh Sanaaee, Saameh Najafi, Sajad Halvaii, Masood Soltani Haghgoo, Alireza Zamany, Marzieh Majidpoor, Jamal Khosravifar, Mina Baniasadi, Mohammad Talebi, Mehrdad Movafagh, Abolfazl Aghaei-Zarch, Seyed Mohsen Khorram, Nastaran Farnia, Poopak Kalhor, Kambiz Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering |
title | Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering |
title_full | Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering |
title_fullStr | Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering |
title_full_unstemmed | Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering |
title_short | Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering |
title_sort | microbiome modulation in inflammatory diseases: progress to microbiome genetic engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640760/ https://www.ncbi.nlm.nih.gov/pubmed/37951913 http://dx.doi.org/10.1186/s12935-023-03095-2 |
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