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Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report

Granulomatous interstitial nephritis is a rare form of tubulointerstitial nephritis and has been uncommonly observed with clozapine usage. Additionally, the progression of the disease to manifest as renal failure requiring dialysis is also uncommon. We describe a case of a 56-year-old female who pre...

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Autores principales: Javed, Nismat, Anto, Anandu M, Nasr, Rabih, Uday, Kalpana A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640836/
https://www.ncbi.nlm.nih.gov/pubmed/38021890
http://dx.doi.org/10.7759/cureus.46971
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author Javed, Nismat
Anto, Anandu M
Nasr, Rabih
Uday, Kalpana A
author_facet Javed, Nismat
Anto, Anandu M
Nasr, Rabih
Uday, Kalpana A
author_sort Javed, Nismat
collection PubMed
description Granulomatous interstitial nephritis is a rare form of tubulointerstitial nephritis and has been uncommonly observed with clozapine usage. Additionally, the progression of the disease to manifest as renal failure requiring dialysis is also uncommon. We describe a case of a 56-year-old female who presented with syncope and was diagnosed with granulomatous interstitial nephritis on biopsy. While hemodialysis may play a role in the management of the disease, steroids provide a definitive treatment. Large-scale studies are needed to evaluate the role of clozapine in causing interstitial nephritis and the characteristics of these features to establish a therapeutic goal.
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spelling pubmed-106408362023-10-13 Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report Javed, Nismat Anto, Anandu M Nasr, Rabih Uday, Kalpana A Cureus Internal Medicine Granulomatous interstitial nephritis is a rare form of tubulointerstitial nephritis and has been uncommonly observed with clozapine usage. Additionally, the progression of the disease to manifest as renal failure requiring dialysis is also uncommon. We describe a case of a 56-year-old female who presented with syncope and was diagnosed with granulomatous interstitial nephritis on biopsy. While hemodialysis may play a role in the management of the disease, steroids provide a definitive treatment. Large-scale studies are needed to evaluate the role of clozapine in causing interstitial nephritis and the characteristics of these features to establish a therapeutic goal. Cureus 2023-10-13 /pmc/articles/PMC10640836/ /pubmed/38021890 http://dx.doi.org/10.7759/cureus.46971 Text en Copyright © 2023, Javed et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Javed, Nismat
Anto, Anandu M
Nasr, Rabih
Uday, Kalpana A
Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report
title Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report
title_full Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report
title_fullStr Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report
title_full_unstemmed Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report
title_short Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report
title_sort clozapine-induced granulomatous interstitial nephritis: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640836/
https://www.ncbi.nlm.nih.gov/pubmed/38021890
http://dx.doi.org/10.7759/cureus.46971
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