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Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report
Granulomatous interstitial nephritis is a rare form of tubulointerstitial nephritis and has been uncommonly observed with clozapine usage. Additionally, the progression of the disease to manifest as renal failure requiring dialysis is also uncommon. We describe a case of a 56-year-old female who pre...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640836/ https://www.ncbi.nlm.nih.gov/pubmed/38021890 http://dx.doi.org/10.7759/cureus.46971 |
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author | Javed, Nismat Anto, Anandu M Nasr, Rabih Uday, Kalpana A |
author_facet | Javed, Nismat Anto, Anandu M Nasr, Rabih Uday, Kalpana A |
author_sort | Javed, Nismat |
collection | PubMed |
description | Granulomatous interstitial nephritis is a rare form of tubulointerstitial nephritis and has been uncommonly observed with clozapine usage. Additionally, the progression of the disease to manifest as renal failure requiring dialysis is also uncommon. We describe a case of a 56-year-old female who presented with syncope and was diagnosed with granulomatous interstitial nephritis on biopsy. While hemodialysis may play a role in the management of the disease, steroids provide a definitive treatment. Large-scale studies are needed to evaluate the role of clozapine in causing interstitial nephritis and the characteristics of these features to establish a therapeutic goal. |
format | Online Article Text |
id | pubmed-10640836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-106408362023-10-13 Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report Javed, Nismat Anto, Anandu M Nasr, Rabih Uday, Kalpana A Cureus Internal Medicine Granulomatous interstitial nephritis is a rare form of tubulointerstitial nephritis and has been uncommonly observed with clozapine usage. Additionally, the progression of the disease to manifest as renal failure requiring dialysis is also uncommon. We describe a case of a 56-year-old female who presented with syncope and was diagnosed with granulomatous interstitial nephritis on biopsy. While hemodialysis may play a role in the management of the disease, steroids provide a definitive treatment. Large-scale studies are needed to evaluate the role of clozapine in causing interstitial nephritis and the characteristics of these features to establish a therapeutic goal. Cureus 2023-10-13 /pmc/articles/PMC10640836/ /pubmed/38021890 http://dx.doi.org/10.7759/cureus.46971 Text en Copyright © 2023, Javed et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Javed, Nismat Anto, Anandu M Nasr, Rabih Uday, Kalpana A Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report |
title | Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report |
title_full | Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report |
title_fullStr | Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report |
title_full_unstemmed | Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report |
title_short | Clozapine-Induced Granulomatous Interstitial Nephritis: A Case Report |
title_sort | clozapine-induced granulomatous interstitial nephritis: a case report |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640836/ https://www.ncbi.nlm.nih.gov/pubmed/38021890 http://dx.doi.org/10.7759/cureus.46971 |
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