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The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review
BACKGROUND: The prevalence of sarcopenia (reduced skeletal muscle strength and mass), Parkinson’s disease (PD) and Parkinson’s related disorders (PRD) all increase with age. They also share risk factors and pathogenetic features. An increased prevalence of sarcopenia in PD and PRD than the general p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641055/ https://www.ncbi.nlm.nih.gov/pubmed/37594550 http://dx.doi.org/10.1007/s10072-023-07007-0 |
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author | Hart, Ashley Cordova-Rivera, Laura Barker, Fred Sayer, Avan A. Granic, Antoneta Yarnall, Alison J. |
author_facet | Hart, Ashley Cordova-Rivera, Laura Barker, Fred Sayer, Avan A. Granic, Antoneta Yarnall, Alison J. |
author_sort | Hart, Ashley |
collection | PubMed |
description | BACKGROUND: The prevalence of sarcopenia (reduced skeletal muscle strength and mass), Parkinson’s disease (PD) and Parkinson’s related disorders (PRD) all increase with age. They also share risk factors and pathogenetic features. An increased prevalence of sarcopenia in PD and PRD than the general population was thus postulated. METHODS: Four databases were searched using predefined literature search strategies. Studies conducted in participants with PD or PRD reporting the prevalence of sarcopenia and those providing data to compute the prevalence were included. Pre-sarcopenia, probable/possible sarcopenia and confirmed sarcopenia were defined according to the main sarcopenia working groups. Risk of bias was assessed using the AXIS tool. RESULTS: 1978 studies were identified; 97 assessed in full; 14 met inclusion criteria. The median study quality score was 15/20. The range of probable sarcopenia was 23.9 to 66.7%, and it did not change after excluding PRD participants. The prevalence of confirmed sarcopenia in participants with any parkinsonian disorder ranged from 2 to 31.4%. Including just PD participants, the range was 10.9 to 31.4%. In studies with controls, sarcopenia was more prevalent in PD and PRD. There was a positive non-significant trend between severity of motor symptoms and prevalence of sarcopenia or components of sarcopenia. High heterogeneity precluded meta-analysis, therefore there was insufficient evidence to conclude whether sarcopenia is more prevalent in PD or PRD. CONCLUSIONS: Probable and confirmed sarcopenia are common in PD and PRD and they may be associated with disease severity. This co-occurrence supports the value of screening for sarcopenia in parkinsonian populations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-023-07007-0. |
format | Online Article Text |
id | pubmed-10641055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-106410552023-11-14 The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review Hart, Ashley Cordova-Rivera, Laura Barker, Fred Sayer, Avan A. Granic, Antoneta Yarnall, Alison J. Neurol Sci Review Article BACKGROUND: The prevalence of sarcopenia (reduced skeletal muscle strength and mass), Parkinson’s disease (PD) and Parkinson’s related disorders (PRD) all increase with age. They also share risk factors and pathogenetic features. An increased prevalence of sarcopenia in PD and PRD than the general population was thus postulated. METHODS: Four databases were searched using predefined literature search strategies. Studies conducted in participants with PD or PRD reporting the prevalence of sarcopenia and those providing data to compute the prevalence were included. Pre-sarcopenia, probable/possible sarcopenia and confirmed sarcopenia were defined according to the main sarcopenia working groups. Risk of bias was assessed using the AXIS tool. RESULTS: 1978 studies were identified; 97 assessed in full; 14 met inclusion criteria. The median study quality score was 15/20. The range of probable sarcopenia was 23.9 to 66.7%, and it did not change after excluding PRD participants. The prevalence of confirmed sarcopenia in participants with any parkinsonian disorder ranged from 2 to 31.4%. Including just PD participants, the range was 10.9 to 31.4%. In studies with controls, sarcopenia was more prevalent in PD and PRD. There was a positive non-significant trend between severity of motor symptoms and prevalence of sarcopenia or components of sarcopenia. High heterogeneity precluded meta-analysis, therefore there was insufficient evidence to conclude whether sarcopenia is more prevalent in PD or PRD. CONCLUSIONS: Probable and confirmed sarcopenia are common in PD and PRD and they may be associated with disease severity. This co-occurrence supports the value of screening for sarcopenia in parkinsonian populations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-023-07007-0. Springer International Publishing 2023-08-18 2023 /pmc/articles/PMC10641055/ /pubmed/37594550 http://dx.doi.org/10.1007/s10072-023-07007-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Hart, Ashley Cordova-Rivera, Laura Barker, Fred Sayer, Avan A. Granic, Antoneta Yarnall, Alison J. The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review |
title | The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review |
title_full | The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review |
title_fullStr | The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review |
title_full_unstemmed | The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review |
title_short | The prevalence of sarcopenia in Parkinson’s disease and related disorders- a systematic review |
title_sort | prevalence of sarcopenia in parkinson’s disease and related disorders- a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641055/ https://www.ncbi.nlm.nih.gov/pubmed/37594550 http://dx.doi.org/10.1007/s10072-023-07007-0 |
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