CRISPR-broad: combined design of multi-targeting gRNAs and broad, multiplex target finding

In CRISPR-Cas and related nuclease-mediated genome editing, target recognition is based on guide RNAs (gRNAs) that are complementary to selected DNA regions. While single site targeting is fundamental for localized genome editing, targeting to expanded and multiple chromosome elements is desirable f...

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Detalles Bibliográficos
Autores principales: Veluchamy, Alaguraj, Teles, Kaian, Fischle, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641073/
https://www.ncbi.nlm.nih.gov/pubmed/37953351
http://dx.doi.org/10.1038/s41598-023-46212-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641073/
https://www.ncbi.nlm.nih.gov/pubmed/37953351
http://dx.doi.org/10.1038/s41598-023-46212-x

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