Cargando…
CRISPR-broad: combined design of multi-targeting gRNAs and broad, multiplex target finding
In CRISPR-Cas and related nuclease-mediated genome editing, target recognition is based on guide RNAs (gRNAs) that are complementary to selected DNA regions. While single site targeting is fundamental for localized genome editing, targeting to expanded and multiple chromosome elements is desirable f...
Autores principales: | Veluchamy, Alaguraj, Teles, Kaian, Fischle, Wolfgang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641073/ https://www.ncbi.nlm.nih.gov/pubmed/37953351 http://dx.doi.org/10.1038/s41598-023-46212-x |
Ejemplares similares
-
Designing broad-spectrum anti-HIV-1 gRNAs to target patient-derived variants
por: Dampier, Will, et al.
Publicado: (2017) -
Novel gRNA design pipeline to develop broad-spectrum CRISPR/Cas9 gRNAs for safe targeting of the HIV-1 quasispecies in patients
por: Sullivan, Neil T., et al.
Publicado: (2019) -
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
por: Champer, Samuel E., et al.
Publicado: (2020) -
Designed gRNAs for CRISPR-Cas9 based antifungal resistance in eggplant
por: Prajapati, Archana, et al.
Publicado: (2023) -
Computational Design of gRNAs Targeting Genetic Variants Across HIV-1 Subtypes for CRISPR-Mediated Antiviral Therapy
por: Chung, Cheng-Han, et al.
Publicado: (2021)