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CRISPR-broad: combined design of multi-targeting gRNAs and broad, multiplex target finding
In CRISPR-Cas and related nuclease-mediated genome editing, target recognition is based on guide RNAs (gRNAs) that are complementary to selected DNA regions. While single site targeting is fundamental for localized genome editing, targeting to expanded and multiple chromosome elements is desirable f...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641073/ https://www.ncbi.nlm.nih.gov/pubmed/37953351 http://dx.doi.org/10.1038/s41598-023-46212-x |