A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo

The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular genetic tool...

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Detalles Bibliográficos
Autores principales: Lagunas, Tomas, Plassmeyer, Stephen P., Fischer, Anthony D., Friedman, Ryan Z., Rieger, Michael A., Selmanovic, Din, Sarafinovska, Simona, Sol, Yvette K., Kasper, Michael J., Fass, Stuart B., Aguilar Lucero, Alessandra F., An, Joon-Yong, Sanders, Stephan J., Cohen, Barak A., Dougherty, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641075/
https://www.ncbi.nlm.nih.gov/pubmed/37953348
http://dx.doi.org/10.1038/s42003-023-05483-w

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