Cargando…

A method for measurement of human asparagine synthetase (ASNS) activity and application to ASNS protein variants associated with ASNS deficiency

Human asparagine synthetase (ASNS) catalyzes the conversion of aspartate to asparagine in an ATP-dependent reaction that utilizes glutamine as a nitrogen source while generating glutamate, AMP, and pyrophosphate as additional products. Asparagine Synthetase Deficiency (ASNSD) is an inborn error of m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Mario C, Staklinski, Stephen J, Merritt, Matthew E, Kilberg, Michael S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Methods Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641120/ https://www.ncbi.nlm.nih.gov/pubmed/37965492 http://dx.doi.org/10.1093/biomethods/bpad026

Ejemplares similares

Novel Mutations in the Asparagine Synthetase Gene (ASNS) Associated With Microcephaly
por: Schleinitz, Dorit, et al.
Publicado: (2018)

Saccharomyces cerevisiae ASN1 and ASN2 are asparagine synthetase paralogs that have diverged in their ability to polymerize in response to nutrient stress
por: Noree, Chalongrat, et al.
Publicado: (2019)

A novel compound heterozygous missense mutation in ASNS broadens the spectrum of asparagine synthetase deficiency
por: Wang, Chun, et al.
Publicado: (2020)

Case report: A compound heterozygous mutations in ASNS broadens the spectrum of asparagine synthetase deficiency in the prenatal diagnosis
por: Zhu, Linyan, et al.
Publicado: (2023)

Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells
por: Chang, Mario C., et al.
Publicado: (2023)

Asn(12) and Asn(278): Critical Residues for In Vitro Biological Activity of Reteplase
por: Mandi, Naganath, et al.
Publicado: (2010)

Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines
por: Staklinski, Stephen J., et al.
Publicado: (2023)

Utility of AlphaMissense predictions in Asparagine Synthetase deficiency variant classification
por: Staklinski, Stephen J., et al.
Publicado: (2023)

ASN guidelines on P values
por: Verhoef, Hans, et al.
Publicado: (2022)

Wheat with greatly reduced accumulation of free asparagine in the grain, produced by CRISPR/Cas9 editing of asparagine synthetase gene TaASN2
por: Raffan, Sarah, et al.
Publicado: (2021)

Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase
por: Tjondro, Harry C., et al.
Publicado: (2020)

Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency
por: Staklinski, Stephen J., et al.
Publicado: (2022)

OsASN1 Plays a Critical Role in Asparagine-Dependent Rice Development
por: Luo, Le, et al.
Publicado: (2018)

1408. Population Pharmacokinetic (PK) Model to Describe Epithelial Lining Fluid (ELF) Penetration of ASN-1 and ASN-2 after ASN100 Administration to Healthy Subjects
por: Van Wart, Scott A, et al.
Publicado: (2018)

Transposon Mutagenesis of Probiotic Lactobacillus casei Identifies asnH, an Asparagine Synthetase Gene Involved in Its Immune-Activating Capacity
por: Ito, Masahiro, et al.
Publicado: (2014)

2021 ASN Virtual Meeting Abstracts
Publicado: (2021)

Clinical outcomes of two patients with a novel pathogenic variant in ASNS: response to asparagine supplementation and review of the literature
por: Sprute, Rosanne, et al.
Publicado: (2019)

Analysis of Enzyme Activity and Cellular Function for the N80S and S480F Asparagine Synthetase Variants Expressed in a Child with Asparagine Synthetase Deficiency
por: Staklinski, Stephen J., et al.
Publicado: (2022)

GlcNAc-Asn is a biomarker for NGLY1 deficiency
por: Mueller, William F, et al.
Publicado: (2021)

Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression
por: Grima-Reyes, Manuel, et al.
Publicado: (2022)

Reduced free asparagine in wheat grain resulting from a natural deletion of TaASN-B2: investigating and exploiting diversity in the asparagine synthetase gene family to improve wheat quality
por: Oddy, Joseph, et al.
Publicado: (2021)

ASN Science Policy Fellows Advocate for Medical Research
por: Brown, Alison, et al.
Publicado: (2018)

ASNS disruption shortens CTPS cytoophidia in Saccharomyces cerevisiae
por: Zhang, Shanshan, et al.
Publicado: (2021)

Glycosylation at Asn254 Is Required for the Activation of the PDGF-C Protein
por: Hu, Wenjie, et al.
Publicado: (2021)

Reliability and Repeatability of the Instrument for the Assessment of Stress in Nursing Students (ASNS)
por: Losa-Iglesias, Marta Elena, et al.
Publicado: (2019)

SAN 2019 Abstract Book for ASN Neuro MAY 2020
Publicado: (2021)

ASN Highlights the Need for Multiple Methods Within Nutrition Research to Advance the Field
por: Coates, Paul M
Publicado: (2022)

The Predatory Bacterium Bdellovibrio bacteriovorus Aspartyl-tRNA Synthetase Recognizes tRNA(Asn) as a Substrate
por: Alperstein, Ariel, et al.
Publicado: (2014)

SELP Asp603Asn and severe thrombosis in COVID-19 males
por: Fallerini, Chiara, et al.
Publicado: (2021)

The importance of Asn52 in the structure–function relationship of human cytochrome c
por: Lou, Dan, et al.
Publicado: (2020)

Monocyte adhesion to atherosclerotic matrix proteins is enhanced by Asn-Gly-Arg deamidation
por: Dutta, Bamaprasad, et al.
Publicado: (2017)

Vitreous amyloidosis caused by a Lys55Asn variant in transthyretin: A case report
por: Tan, Yue, et al.
Publicado: (2022)

Draft Genome Sequence of Propionibacterium acnes subsp. elongatum Strain Asn12
por: McDowell, Andrew, et al.
Publicado: (2018)

Association between the ERCC2 Asp312Asn polymorphism and risk of cancer
por: Xiao, Feifan, et al.
Publicado: (2017)

Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy
por: Zhu, Liqin, et al.
Publicado: (2020)

Penetrance of the ABCA4 p.Asn1868Ile Allele in Stargardt Disease
por: Allikmets, Rando, et al.
Publicado: (2018)

Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway
por: Park, Joon Sung, et al.
Publicado: (2020)

Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions
por: Bredrup, Cecilie, et al.
Publicado: (2021)

Neuropeptide S receptor gene Asn107 polymorphism in obese male individuals in Pakistan
por: Ahmad, Aftab, et al.
Publicado: (2020)

Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL
por: Akahane, Koshi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t0bnd5afu0fvbe04bpe1pkn246