New highlights on stroma–epithelial interactions in breast cancer

Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, w...

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Detalles Bibliográficos
Autores principales: Barcellos-Hoff, Mary Helen, Medina, Daniel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064117/
https://www.ncbi.nlm.nih.gov/pubmed/15642180
http://dx.doi.org/10.1186/bcr972
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author Barcellos-Hoff, Mary Helen
Medina, Daniel
author_facet Barcellos-Hoff, Mary Helen
Medina, Daniel
author_sort Barcellos-Hoff, Mary Helen
collection PubMed
description Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.
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spelling pubmed-10641172005-03-11 New highlights on stroma–epithelial interactions in breast cancer Barcellos-Hoff, Mary Helen Medina, Daniel Breast Cancer Res Commentary Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches. BioMed Central 2005 2004-11-25 /pmc/articles/PMC1064117/ /pubmed/15642180 http://dx.doi.org/10.1186/bcr972 Text en Copyright © 2004 BioMed Central Ltd
spellingShingle Commentary
Barcellos-Hoff, Mary Helen
Medina, Daniel
New highlights on stroma–epithelial interactions in breast cancer
title New highlights on stroma–epithelial interactions in breast cancer
title_full New highlights on stroma–epithelial interactions in breast cancer
title_fullStr New highlights on stroma–epithelial interactions in breast cancer
title_full_unstemmed New highlights on stroma–epithelial interactions in breast cancer
title_short New highlights on stroma–epithelial interactions in breast cancer
title_sort new highlights on stroma–epithelial interactions in breast cancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064117/
https://www.ncbi.nlm.nih.gov/pubmed/15642180
http://dx.doi.org/10.1186/bcr972
work_keys_str_mv AT barcelloshoffmaryhelen newhighlightsonstromaepithelialinteractionsinbreastcancer
AT medinadaniel newhighlightsonstromaepithelialinteractionsinbreastcancer

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