Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome

A 74-year-old woman was admitted with hypercalcemia and prolonged disturbance of consciousness. The left buttock to the anterior aspect of the left thigh was swollen and erythematous, with a collection of 1.0-cm large, firm, elastic nodules distributed in a zosteriform pattern in the L1-L4 region. B...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsuzawa Adachi, Michiko, Sugawara, Hitoshi, Ishii, Akira, Chiba, Emiko, Hamamoto, Kohei, Demitsu, Toshio, Yamada, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641195/
https://www.ncbi.nlm.nih.gov/pubmed/36858515
http://dx.doi.org/10.2169/internalmedicine.0893-22
_version_ 1785146721914847232
author Matsuzawa Adachi, Michiko
Sugawara, Hitoshi
Ishii, Akira
Chiba, Emiko
Hamamoto, Kohei
Demitsu, Toshio
Yamada, Shigeki
author_facet Matsuzawa Adachi, Michiko
Sugawara, Hitoshi
Ishii, Akira
Chiba, Emiko
Hamamoto, Kohei
Demitsu, Toshio
Yamada, Shigeki
author_sort Matsuzawa Adachi, Michiko
collection PubMed
description A 74-year-old woman was admitted with hypercalcemia and prolonged disturbance of consciousness. The left buttock to the anterior aspect of the left thigh was swollen and erythematous, with a collection of 1.0-cm large, firm, elastic nodules distributed in a zosteriform pattern in the L1-L4 region. Based on autopsy findings, a very rare case of Cobb syndrome was diagnosed due to a spinal vascular malformation at the Th12-L4 level and L5 vertebral hemangioma. Cobb syndrome-associated cutaneous metastasis extending along the same metamere was complicated by immunohistochemically proven parathyroid hormone-related protein-producing advanced bladder carcinoma in this case.
format Online
Article
Text
id pubmed-10641195
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-106411952023-11-15 Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome Matsuzawa Adachi, Michiko Sugawara, Hitoshi Ishii, Akira Chiba, Emiko Hamamoto, Kohei Demitsu, Toshio Yamada, Shigeki Intern Med Case Report A 74-year-old woman was admitted with hypercalcemia and prolonged disturbance of consciousness. The left buttock to the anterior aspect of the left thigh was swollen and erythematous, with a collection of 1.0-cm large, firm, elastic nodules distributed in a zosteriform pattern in the L1-L4 region. Based on autopsy findings, a very rare case of Cobb syndrome was diagnosed due to a spinal vascular malformation at the Th12-L4 level and L5 vertebral hemangioma. Cobb syndrome-associated cutaneous metastasis extending along the same metamere was complicated by immunohistochemically proven parathyroid hormone-related protein-producing advanced bladder carcinoma in this case. The Japanese Society of Internal Medicine 2023-03-01 2023-10-15 /pmc/articles/PMC10641195/ /pubmed/36858515 http://dx.doi.org/10.2169/internalmedicine.0893-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsuzawa Adachi, Michiko
Sugawara, Hitoshi
Ishii, Akira
Chiba, Emiko
Hamamoto, Kohei
Demitsu, Toshio
Yamada, Shigeki
Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome
title Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome
title_full Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome
title_fullStr Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome
title_full_unstemmed Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome
title_short Malignancy-related Hypercalcemia Caused by Metameric Cutaneous Metastasis of Parathyroid Hormone-related Protein-producing Bladder Carcinoma with Squamous Cell Differentiation: An Autopsy Case of Cobb Syndrome
title_sort malignancy-related hypercalcemia caused by metameric cutaneous metastasis of parathyroid hormone-related protein-producing bladder carcinoma with squamous cell differentiation: an autopsy case of cobb syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641195/
https://www.ncbi.nlm.nih.gov/pubmed/36858515
http://dx.doi.org/10.2169/internalmedicine.0893-22
work_keys_str_mv AT matsuzawaadachimichiko malignancyrelatedhypercalcemiacausedbymetamericcutaneousmetastasisofparathyroidhormonerelatedproteinproducingbladdercarcinomawithsquamouscelldifferentiationanautopsycaseofcobbsyndrome
AT sugawarahitoshi malignancyrelatedhypercalcemiacausedbymetamericcutaneousmetastasisofparathyroidhormonerelatedproteinproducingbladdercarcinomawithsquamouscelldifferentiationanautopsycaseofcobbsyndrome
AT ishiiakira malignancyrelatedhypercalcemiacausedbymetamericcutaneousmetastasisofparathyroidhormonerelatedproteinproducingbladdercarcinomawithsquamouscelldifferentiationanautopsycaseofcobbsyndrome
AT chibaemiko malignancyrelatedhypercalcemiacausedbymetamericcutaneousmetastasisofparathyroidhormonerelatedproteinproducingbladdercarcinomawithsquamouscelldifferentiationanautopsycaseofcobbsyndrome
AT hamamotokohei malignancyrelatedhypercalcemiacausedbymetamericcutaneousmetastasisofparathyroidhormonerelatedproteinproducingbladdercarcinomawithsquamouscelldifferentiationanautopsycaseofcobbsyndrome
AT demitsutoshio malignancyrelatedhypercalcemiacausedbymetamericcutaneousmetastasisofparathyroidhormonerelatedproteinproducingbladdercarcinomawithsquamouscelldifferentiationanautopsycaseofcobbsyndrome
AT yamadashigeki malignancyrelatedhypercalcemiacausedbymetamericcutaneousmetastasisofparathyroidhormonerelatedproteinproducingbladdercarcinomawithsquamouscelldifferentiationanautopsycaseofcobbsyndrome

Ejemplares similares