The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation

The DNAJB6 chaperone inhibits fibril formation of aggregation-prone client peptides through interaction with aggregated and oligomeric forms of the amyloid peptides. Here, we studied the role of its C-terminal domain (CTD) using constructs comprising either the entire CTD or the first two or all fou...

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Detalles Bibliográficos
Autores principales: Österlund, Nicklas, Frankel, Rebecca, Carlsson, Andreas, Thacker, Dev, Karlsson, Maja, Matus, Vanessa, Gräslund, Astrid, Emanuelsson, Cecilia, Linse, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641233/
https://www.ncbi.nlm.nih.gov/pubmed/37797698
http://dx.doi.org/10.1016/j.jbc.2023.105317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641233/
https://www.ncbi.nlm.nih.gov/pubmed/37797698
http://dx.doi.org/10.1016/j.jbc.2023.105317

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