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Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF

Hypoxic pulmonary hypertension (HPH) lacks effective pharmacologic treatments. Microarray-based gene expression indicates the crucial role of Cullin 5 (Cul 5) in HPH. This study showed that Cul 5 was upregulated in HPH patients and a murine model of HPH. In vitro, Cul 5 promoted the angiogenesis and...

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Detalles Bibliográficos
Autores principales:	Wang, Lei, Huang, Jing, Zhang, Ruoyang, Zhang, Muzhi, Guo, Yu, Liu, Yang, Li, Cong, Wang, Wei, Ying, Sun, Liu, Jie, Wang, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641258/ https://www.ncbi.nlm.nih.gov/pubmed/37965157 http://dx.doi.org/10.1016/j.isci.2023.108199

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