Cargando…

Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF

Hypoxic pulmonary hypertension (HPH) lacks effective pharmacologic treatments. Microarray-based gene expression indicates the crucial role of Cullin 5 (Cul 5) in HPH. This study showed that Cul 5 was upregulated in HPH patients and a murine model of HPH. In vitro, Cul 5 promoted the angiogenesis and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lei, Huang, Jing, Zhang, Ruoyang, Zhang, Muzhi, Guo, Yu, Liu, Yang, Li, Cong, Wang, Wei, Ying, Sun, Liu, Jie, Wang, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641258/ https://www.ncbi.nlm.nih.gov/pubmed/37965157 http://dx.doi.org/10.1016/j.isci.2023.108199

Ejemplares similares

Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells
por: Jiang, Yuan, et al.
Publicado: (2015)

IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells
por: Liu, Jie, et al.
Publicado: (2018)

HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6
por: D’Ignazio, Laura, et al.
Publicado: (2020)

TRAF6 neddylation drives inflammatory arthritis by increasing NF-κB activation
por: Liu, Kewei, et al.
Publicado: (2019)

Hypoxic Regulation of VEGF, HIF-1(alpha) in Coronary Collaterals Development
por: Sung, Ki Chul, et al.
Publicado: (2005)

Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF-1α and VEGF expression
por: Dong, Dan, et al.
Publicado: (2021)

Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling
por: Wang, Rui, et al.
Publicado: (2022)

Relationship between the expression of CD133, HIF-1α, VEGF and the proliferation and apoptosis in hypoxic human prostate cancer cells
por: Liu, Lingyun, et al.
Publicado: (2017)

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions
por: Dong, Xiao, et al.
Publicado: (2011)

IL-33-HIF1α Axis in Hypoxic Pulmonary Hypertension
por: Kumar, Rahul, et al.
Publicado: (2018)

TRAF2 is an NF-κB activating oncogene in epithelial cancers
por: Shen, Rhine R., et al.
Publicado: (2013)

miRNA-29 aggravates myocardial infarction via inhibiting the PI3K/mTOR/HIF1α/VEGF pathway
por: Wang, Xiaoxi, et al.
Publicado: (2022)

ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization
por: Liu, Enping, et al.
Publicado: (2021)

Down-regulated cylindromatosis enhances NF-κB activation and aggravates inflammation in HBV-ACLF patients
por: Zhang, Xueyun, et al.
Publicado: (2022)

COMMD3 Expression Affects Angiogenesis through the HIF1α/VEGF/NF-κB Signaling Pathway in Hepatocellular Carcinoma In Vitro and In Vivo
por: Zhu, Tingting, et al.
Publicado: (2022)

The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation
por: Thomas, Ranjeny
Publicado: (2005)

SHARPIN Negatively Associates with TRAF2-Mediated NFκB Activation
por: Liang, Yanhua
Publicado: (2011)

Corrigendum: ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization
por: Liu, Enping, et al.
Publicado: (2021)

CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
por: Luo, Yongting, et al.
Publicado: (2019)

Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes
por: Wang, Pengzhen, et al.
Publicado: (2020)

BICP0 Negatively Regulates TRAF6-Mediated NF-κB and Interferon Activation by Promoting K48-Linked Polyubiquitination of TRAF6
por: Cao, Chong, et al.
Publicado: (2020)

The Scaffold Protein TANK/I-TRAF Inhibits NF-κB Activation by Recruiting Polo-like Kinase 1
por: Zhang, Wanqiao, et al.
Publicado: (2010)

PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis
por: Jin, Kangpeng, et al.
Publicado: (2020)

Hypoxic Pretreatment of Adipose-Derived Stem Cells Accelerates Diabetic Wound Healing via circ-Gcap14 and HIF-1α/VEGF Mediated Angiopoiesis
por: Wang, Zhi, et al.
Publicado: (2021)

SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases
por: Wu, Weijun, et al.
Publicado: (2021)

Otud7b controls noncanonical NF-κB activation via deubiquitination of TRAF3
por: Hu, Hongbo, et al.
Publicado: (2013)

NF‐κB and HIF crosstalk in immune responses
por: D'Ignazio, Laura, et al.
Publicado: (2015)

Dihydroartemisinin inhibits activation of the AIM2 inflammasome pathway and NF-κB/HIF-1α/VEGF pathway by inducing autophagy in A431 human cutaneous squamous cell carcinoma cells
por: Wang, Yajie, et al.
Publicado: (2021)

Rescue of TRAF3-null mice by p100 NF-κB deficiency
por: He, Jeannie Q., et al.
Publicado: (2006)

Cathepsin B aggravated doxorubicin-induced myocardial injury via NF-κB signalling
por: Liu, Chen, et al.
Publicado: (2020)

PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis: Erratum
por: Jin, Kangpeng, et al.
Publicado: (2022)

STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway
por: Liu, Yang, et al.
Publicado: (2017)

Therapeutic Role and Potential Mechanism of Resveratrol in Atherosclerosis: TLR4/NF-κB/HIF-1α
por: Guo, Lin, et al.
Publicado: (2023)

Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep
por: He, Yanyu, et al.
Publicado: (2019)

Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
por: Fu, Lingyi, et al.
Publicado: (2013)

Effect of the Recombinant Adenovirus-Mediated HIF-1 Alpha on the Expression of VEGF in the Hypoxic Brain Microvascular Endothelial Cells of Rats
por: Jin, Ming-Lu, et al.
Publicado: (2020)

C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6
por: Jang, Hyun-Duk, et al.
Publicado: (2019)

Morroniside Inhibits Inflammatory Bone Loss through the TRAF6-Mediated NF-κB/MAPK Signalling Pathway
por: Xiao, Jirimutu, et al.
Publicado: (2023)

The natural compound Sanggenon C inhibits PRRSV infection by regulating the TRAF2/NF-κB signalling pathway
por: Liu, Xiao, et al.
Publicado: (2023)

Naringenin attenuates inflammation and apoptosis of osteoarthritic chondrocytes via the TLR4/TRAF6/NF-κB pathway
por: Wang, Yan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rj07nr81rhrim79s7gt2mme8f6