Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43

The cytoplasmic accumulation of the nuclear protein transactive response DNA-binding protein 43 kDa (TDP-43) has been linked to the progression of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 secreted into the extracellular space has been suggested to contribute to the...

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Detalles Bibliográficos
Autores principales: Tanaka, Yoshinori, Ito, Shun-ichi, Honma, Yuki, Hasegawa, Masato, Kametani, Fuyuki, Suzuki, Genjiro, Kozuma, Lina, Takeya, Kosuke, Eto, Masumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641265/
https://www.ncbi.nlm.nih.gov/pubmed/37739033
http://dx.doi.org/10.1016/j.jbc.2023.105272

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