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Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

INTRODUCTION: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity, which is required for the ubiquitination of securin and cyclin-B. Moreover, the mitotic spindle checkpoint is activated if APC activation is prevented. In addition, several APC-targeting m...

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Detalles Bibliográficos
Autores principales:	Park, Kwang-Hwa, Choi, Sung-E, Eom, Minseob, Kang, Yup
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064132/ https://www.ncbi.nlm.nih.gov/pubmed/15743504 http://dx.doi.org/10.1186/bcr978

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