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Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair

This review delves into the intersection of two prevalent conditions, hyperlipidemia and rotator cuff injuries, both of which bear substantial healthcare burdens. Our investigation begins with an exploration of rotator cuff injuries, common musculoskeletal disorders that severely impair shoulder fun...

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Detalles Bibliográficos
Autores principales: Qian, Yinhua, Huang, Haoqiang, Wan, Renwen, Zhou, Yu, Feng, Xinting, Xu, Feng, Luo, Zhiwen, Wang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641405/
https://www.ncbi.nlm.nih.gov/pubmed/37965515
http://dx.doi.org/10.3389/fpubh.2023.1279118
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author Qian, Yinhua
Huang, Haoqiang
Wan, Renwen
Zhou, Yu
Feng, Xinting
Xu, Feng
Luo, Zhiwen
Wang, Qing
author_facet Qian, Yinhua
Huang, Haoqiang
Wan, Renwen
Zhou, Yu
Feng, Xinting
Xu, Feng
Luo, Zhiwen
Wang, Qing
author_sort Qian, Yinhua
collection PubMed
description This review delves into the intersection of two prevalent conditions, hyperlipidemia and rotator cuff injuries, both of which bear substantial healthcare burdens. Our investigation begins with an exploration of rotator cuff injuries, common musculoskeletal disorders that severely impair shoulder functionality and quality of life. These injuries are notably pervasive among sports enthusiasts and the older adult, with an incidence rate estimated at 5–10% in the general population. Despite their widespread occurrence and the diverse, multifactorial etiological factors, effective treatment strategies remain elusive. We then examine hyperlipidemia, a metabolic disorder affecting approximately 40% of the global adult population. Characterized by elevated levels of cholesterol and triglycerides, hyperlipidemia can precipitate severe cardiovascular complications and presents a significant socioeconomic burden. Although current management strategies encompass lifestyle modifications and pharmacological interventions, the condition remains a formidable health challenge. Central to this review is the exploration of a potential association between hyperlipidemia and rotator cuff injuries. We aim to synthesize the current understanding of hyperlipidemia’s role in the pathophysiology of rotator cuff injuries, thereby offering fresh insights into their common etiological underpinnings, potential therapeutic targets, and drugs, such as Statins. The influence of other lipid-lowering therapeutics on tendon health is also considered, and further research into the molecular pathways and potential therapeutic benefits of these drugs is required. This pursuit aligns with broader efforts to enhance patient outcomes, minimize healthcare burdens, and contribute to the global understanding of these prevalent conditions.
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spelling pubmed-106414052023-11-14 Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair Qian, Yinhua Huang, Haoqiang Wan, Renwen Zhou, Yu Feng, Xinting Xu, Feng Luo, Zhiwen Wang, Qing Front Public Health Public Health This review delves into the intersection of two prevalent conditions, hyperlipidemia and rotator cuff injuries, both of which bear substantial healthcare burdens. Our investigation begins with an exploration of rotator cuff injuries, common musculoskeletal disorders that severely impair shoulder functionality and quality of life. These injuries are notably pervasive among sports enthusiasts and the older adult, with an incidence rate estimated at 5–10% in the general population. Despite their widespread occurrence and the diverse, multifactorial etiological factors, effective treatment strategies remain elusive. We then examine hyperlipidemia, a metabolic disorder affecting approximately 40% of the global adult population. Characterized by elevated levels of cholesterol and triglycerides, hyperlipidemia can precipitate severe cardiovascular complications and presents a significant socioeconomic burden. Although current management strategies encompass lifestyle modifications and pharmacological interventions, the condition remains a formidable health challenge. Central to this review is the exploration of a potential association between hyperlipidemia and rotator cuff injuries. We aim to synthesize the current understanding of hyperlipidemia’s role in the pathophysiology of rotator cuff injuries, thereby offering fresh insights into their common etiological underpinnings, potential therapeutic targets, and drugs, such as Statins. The influence of other lipid-lowering therapeutics on tendon health is also considered, and further research into the molecular pathways and potential therapeutic benefits of these drugs is required. This pursuit aligns with broader efforts to enhance patient outcomes, minimize healthcare burdens, and contribute to the global understanding of these prevalent conditions. Frontiers Media S.A. 2023-10-27 /pmc/articles/PMC10641405/ /pubmed/37965515 http://dx.doi.org/10.3389/fpubh.2023.1279118 Text en Copyright © 2023 Qian, Huang, Wan, Zhou, Feng, Xu, Luo and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Qian, Yinhua
Huang, Haoqiang
Wan, Renwen
Zhou, Yu
Feng, Xinting
Xu, Feng
Luo, Zhiwen
Wang, Qing
Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair
title Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair
title_full Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair
title_fullStr Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair
title_full_unstemmed Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair
title_short Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair
title_sort progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641405/
https://www.ncbi.nlm.nih.gov/pubmed/37965515
http://dx.doi.org/10.3389/fpubh.2023.1279118
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