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Selective head cooling in the acute phase of concussive injury: a neuroimaging study
INTRODUCTION: Neurovascular decoupling is a common consequence after brain injuries like sports-related concussion. Failure to appropriately match cerebral blood flow (CBF) with increases in metabolic demands of the brain can lead to alterations in neurological function and symptom presentation. The...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641407/ https://www.ncbi.nlm.nih.gov/pubmed/37965166 http://dx.doi.org/10.3389/fneur.2023.1272374 |
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author | Walter, Alexa E. Bai, Xiaoxiao Wilkes, James Neuberger, Thomas Sebastianelli, Wayne Slobounov, Semyon M. |
author_facet | Walter, Alexa E. Bai, Xiaoxiao Wilkes, James Neuberger, Thomas Sebastianelli, Wayne Slobounov, Semyon M. |
author_sort | Walter, Alexa E. |
collection | PubMed |
description | INTRODUCTION: Neurovascular decoupling is a common consequence after brain injuries like sports-related concussion. Failure to appropriately match cerebral blood flow (CBF) with increases in metabolic demands of the brain can lead to alterations in neurological function and symptom presentation. Therapeutic hypothermia has been used in medicine for neuroprotection and has been shown to improve outcome. This study aimed to examine the real time effect of selective head cooling on healthy controls and concussed athletes via magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) measures. METHODS: 24 participants (12 controls; 12 concussed) underwent study procedures including the Post-Concussion Symptom Severity (PCSS) Rating Form and an MRI cooling protocol (pre-cooling (T1 MPRAGE, ASL, single volume spectroscopy (SVS)); during cooling (ASL, SVS)). RESULTS: Results showed general decreases in brain temperature as a function of time for both groups. Repeated measures ANOVA showed a significant main effect of time (F = 7.94, p < 0.001) and group (F = 22.21, p < 0.001) on temperature, but no significant interaction of group and time (F = 1.36, p = 0.237). CBF assessed via ASL was non-significantly lower in concussed individuals at pre-cooling and generalized linear mixed model analyses demonstrated a significant main effect of time for the occipital left ROI (F = 11.29, p = 0.002) and occipital right ROI (F = 13.39, p = 0.001). There was no relationship between any MRI metric and PCSS symptom burden. DISCUSSION: These findings suggest the feasibility of MRS thermometry to monitor alterations of brain temperature in concussed athletes and that metabolic responses in response to cooling after concussion may differ from controls. |
format | Online Article Text |
id | pubmed-10641407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106414072023-11-14 Selective head cooling in the acute phase of concussive injury: a neuroimaging study Walter, Alexa E. Bai, Xiaoxiao Wilkes, James Neuberger, Thomas Sebastianelli, Wayne Slobounov, Semyon M. Front Neurol Neurology INTRODUCTION: Neurovascular decoupling is a common consequence after brain injuries like sports-related concussion. Failure to appropriately match cerebral blood flow (CBF) with increases in metabolic demands of the brain can lead to alterations in neurological function and symptom presentation. Therapeutic hypothermia has been used in medicine for neuroprotection and has been shown to improve outcome. This study aimed to examine the real time effect of selective head cooling on healthy controls and concussed athletes via magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) measures. METHODS: 24 participants (12 controls; 12 concussed) underwent study procedures including the Post-Concussion Symptom Severity (PCSS) Rating Form and an MRI cooling protocol (pre-cooling (T1 MPRAGE, ASL, single volume spectroscopy (SVS)); during cooling (ASL, SVS)). RESULTS: Results showed general decreases in brain temperature as a function of time for both groups. Repeated measures ANOVA showed a significant main effect of time (F = 7.94, p < 0.001) and group (F = 22.21, p < 0.001) on temperature, but no significant interaction of group and time (F = 1.36, p = 0.237). CBF assessed via ASL was non-significantly lower in concussed individuals at pre-cooling and generalized linear mixed model analyses demonstrated a significant main effect of time for the occipital left ROI (F = 11.29, p = 0.002) and occipital right ROI (F = 13.39, p = 0.001). There was no relationship between any MRI metric and PCSS symptom burden. DISCUSSION: These findings suggest the feasibility of MRS thermometry to monitor alterations of brain temperature in concussed athletes and that metabolic responses in response to cooling after concussion may differ from controls. Frontiers Media S.A. 2023-10-27 /pmc/articles/PMC10641407/ /pubmed/37965166 http://dx.doi.org/10.3389/fneur.2023.1272374 Text en Copyright © 2023 Walter, Bai, Wilkes, Neuberger, Sebastianelli and Slobounov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Walter, Alexa E. Bai, Xiaoxiao Wilkes, James Neuberger, Thomas Sebastianelli, Wayne Slobounov, Semyon M. Selective head cooling in the acute phase of concussive injury: a neuroimaging study |
title | Selective head cooling in the acute phase of concussive injury: a neuroimaging study |
title_full | Selective head cooling in the acute phase of concussive injury: a neuroimaging study |
title_fullStr | Selective head cooling in the acute phase of concussive injury: a neuroimaging study |
title_full_unstemmed | Selective head cooling in the acute phase of concussive injury: a neuroimaging study |
title_short | Selective head cooling in the acute phase of concussive injury: a neuroimaging study |
title_sort | selective head cooling in the acute phase of concussive injury: a neuroimaging study |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641407/ https://www.ncbi.nlm.nih.gov/pubmed/37965166 http://dx.doi.org/10.3389/fneur.2023.1272374 |
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