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Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers

Surgical resection can lead to prolonged survival in patients with isolated liver metastases (LM) from various primary cancers. However, there are currently no validated predictive markers to discriminate between these oligo/argometastatic patients, who will benefit from surgery, and those with diff...

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Autores principales: Bohlok, Ali, Richard, François, Lucidi, Valerio, Asmar, Antoine El, Demetter, Pieter, Craciun, Ligia, Larsimont, Denis, Hendlisz, Alain, Van Laethem, Jean Luc, Dirix, Luc, Desmedt, Christine, Vermeulen, Peter, Donckier, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641477/
https://www.ncbi.nlm.nih.gov/pubmed/37965465
http://dx.doi.org/10.3389/fonc.2023.1260880
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author Bohlok, Ali
Richard, François
Lucidi, Valerio
Asmar, Antoine El
Demetter, Pieter
Craciun, Ligia
Larsimont, Denis
Hendlisz, Alain
Van Laethem, Jean Luc
Dirix, Luc
Desmedt, Christine
Vermeulen, Peter
Donckier, Vincent
author_facet Bohlok, Ali
Richard, François
Lucidi, Valerio
Asmar, Antoine El
Demetter, Pieter
Craciun, Ligia
Larsimont, Denis
Hendlisz, Alain
Van Laethem, Jean Luc
Dirix, Luc
Desmedt, Christine
Vermeulen, Peter
Donckier, Vincent
author_sort Bohlok, Ali
collection PubMed
description Surgical resection can lead to prolonged survival in patients with isolated liver metastases (LM) from various primary cancers. However, there are currently no validated predictive markers to discriminate between these oligo/argometastatic patients, who will benefit from surgery, and those with diffuse metastatic behavior in whom surgery will be futile. To evaluate whether the tumor microenvironment, or histopathological growth pattern (HGP), of LM reflects the type of metastatic progression independently of the origin of the primary cancer, we analyzed a combined series of patients who underwent surgery for colorectal LM (N=263) or non-colorectal LM (N=66). HGPs of LM were scored in each patient to distinguish between desmoplastic HGP (all LM showing a complete encapsulated pattern) and non-desmoplastic HGP (at least one LM with some infiltrating-replacement component). In the entire series, 5-year overall and progression-free survival were, 44.5% and 15.5%, respectively, with no significant differences between colorectal and non-colorectal LM. In patients with desmoplastic HGP, 5-year overall and progression-free survival were 57% and 32%, respectively, as compared to 41% and 12%, respectively, in patients with non-desmoplastic-HGP (p=0.03 and 0.005). Irrespective of cancer origin and compared to traditional risk factors, desmoplastic HGP was the most significant predictor for better post-operative overall survival (adjusted HR: 0.62; 95% CI: [0.49-0.97]; p=0.035) and progression-free survival (adjusted HR: 0.61; 95% CI: [0.42-0.87], p=0.006). This suggests that the HGP of LM may represent an accurate marker that reflects the mode of metastatic behavior, independently of primary cancer type.
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spelling pubmed-106414772023-11-14 Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers Bohlok, Ali Richard, François Lucidi, Valerio Asmar, Antoine El Demetter, Pieter Craciun, Ligia Larsimont, Denis Hendlisz, Alain Van Laethem, Jean Luc Dirix, Luc Desmedt, Christine Vermeulen, Peter Donckier, Vincent Front Oncol Oncology Surgical resection can lead to prolonged survival in patients with isolated liver metastases (LM) from various primary cancers. However, there are currently no validated predictive markers to discriminate between these oligo/argometastatic patients, who will benefit from surgery, and those with diffuse metastatic behavior in whom surgery will be futile. To evaluate whether the tumor microenvironment, or histopathological growth pattern (HGP), of LM reflects the type of metastatic progression independently of the origin of the primary cancer, we analyzed a combined series of patients who underwent surgery for colorectal LM (N=263) or non-colorectal LM (N=66). HGPs of LM were scored in each patient to distinguish between desmoplastic HGP (all LM showing a complete encapsulated pattern) and non-desmoplastic HGP (at least one LM with some infiltrating-replacement component). In the entire series, 5-year overall and progression-free survival were, 44.5% and 15.5%, respectively, with no significant differences between colorectal and non-colorectal LM. In patients with desmoplastic HGP, 5-year overall and progression-free survival were 57% and 32%, respectively, as compared to 41% and 12%, respectively, in patients with non-desmoplastic-HGP (p=0.03 and 0.005). Irrespective of cancer origin and compared to traditional risk factors, desmoplastic HGP was the most significant predictor for better post-operative overall survival (adjusted HR: 0.62; 95% CI: [0.49-0.97]; p=0.035) and progression-free survival (adjusted HR: 0.61; 95% CI: [0.42-0.87], p=0.006). This suggests that the HGP of LM may represent an accurate marker that reflects the mode of metastatic behavior, independently of primary cancer type. Frontiers Media S.A. 2023-10-27 /pmc/articles/PMC10641477/ /pubmed/37965465 http://dx.doi.org/10.3389/fonc.2023.1260880 Text en Copyright © 2023 Bohlok, Richard, Lucidi, Asmar, Demetter, Craciun, Larsimont, Hendlisz, Van Laethem, Dirix, Desmedt, Vermeulen and Donckier https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bohlok, Ali
Richard, François
Lucidi, Valerio
Asmar, Antoine El
Demetter, Pieter
Craciun, Ligia
Larsimont, Denis
Hendlisz, Alain
Van Laethem, Jean Luc
Dirix, Luc
Desmedt, Christine
Vermeulen, Peter
Donckier, Vincent
Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers
title Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers
title_full Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers
title_fullStr Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers
title_full_unstemmed Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers
title_short Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers
title_sort histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641477/
https://www.ncbi.nlm.nih.gov/pubmed/37965465
http://dx.doi.org/10.3389/fonc.2023.1260880
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