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Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability

Patients with OA and varus knees are subject to abnormal mechanical environment and objective of this study was to investigate the molecular mechanisms underlying chondrocyte senescence caused by mechanical overloading and the role of Zmpste24-mediated nuclear membrane instability in varus knees. Fi...

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Detalles Bibliográficos
Autores principales:	Kong, Keyu, Jin, Minghao, Zhao, Chen, Qiao, Hua, Chen, Xuzhuo, Li, Baixing, Rong, Kewei, Zhang, Pu, Shan, Yu, Xu, Zhengquan, Chang, Yongyun, Li, Huiwu, Zhai, Zanjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641493/ https://www.ncbi.nlm.nih.gov/pubmed/37965144 http://dx.doi.org/10.1016/j.isci.2023.108119

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