Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

Gastroesophageal adenocarcinoma (GEA) is an aggressive malignancy with chromosomal instability (CIN). To understand adaptive responses enabling DNA damage response (DDR) and CIN, we analyzed matched normal, premalignant, and malignant gastric lesions from human specimens and a carcinogen-induced mou...

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Detalles Bibliográficos
Autores principales: Sahgal, Pranshu, Patil, Deepa T., Bala, Pratyusha, Sztupinszki, Zsofia M., Tisza, Viktoria, Spisak, Sandor, Luong, Anna G., Huffman, Brandon, Prosz, Aurel, Singh, Harshabad, Lazaro, Jean-Bernard, Szallasi, Zoltan, Cleary, James M., Sethi, Nilay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641495/
https://www.ncbi.nlm.nih.gov/pubmed/37965133
http://dx.doi.org/10.1016/j.isci.2023.108169

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